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Alphaherpesvirinae

Pseudorabies

QuestionAnswer
What are two other names for this disease? Aujeszky's Disease and "Mad Itch"
Who is this primarily a disease of and what is special about this? Swine and it is REPORTABLE
Does this disease occur worldwide or locally? Worldwide!
How long can this virus survive in the environment and who is the most sensitive lab animal? few hours to 2-3 days and the RABBIT!
Who are the primary hosts and resevoirs of this virus? Who is the minor resevoir? Recovered adult pigs// Rodents (brown rats)
What is the single most important factor in the trasmission of pseudorabies? spread of the virus from swine to other species and to other swine
How is it spread through swine?` nasal secretions (especially recovered), saliva, and milk// licking abraded skin, biting, aerosols, and ingestion of infected carcasses and contaminated water and feed
How are dogs and cats infected? ingestion of infected pif carcasses and rodents
How are ruminants infected? direct contact with pigs//oral and nasal routes
Why is this virus easy to eradicate? IT ONLY REPLICATES IN SWINE!
Where does the cirus replicate in the pig? URT...specifically the epithelium of the nasopharynx and tonsils which then spread to the lnn. and the CNS
There is a brief viremia and then the virus spread to the CNS and causes 3 things: (1) Ganglioneuritis/ (2) Nonsuppourative meningoencephalitis/ (3) Perivascular cuffing
What are the clinical features in weaned, growing, and adult swine? Listless, depressed, incoordination, circling, convulsions, mortality (<2%)/ Puritus is rare in pigs, but is a common secondary disease in other hosts
What are the clinical features in piglets born to nonimmune sows? Death within 24 hours after parturition// Mortality reaches 100%
What are the clinical features in nonimmune pregnant sows? SMEDI and 50% can abort
What happens if nonimmune sows are infected before 30days of gestation? DEATH and resorption of embryos
What happens in nonimmune sows aer infected in late pregnancy? Deliver mummified, macerated, stillborn, weak, or normal swine.
What does SMEDI stand for?` Stillbirth. Mummification. Enbryonic Death. Infertility.
T/F. Less than 20% of cows aborting are infertiles on and the next breeding and never conceive again. FALSE- They do eventually conceive!
What are the clinical features in cattle? "Mad Itch". INTENSE puritus of the head and neck due to respiratory infection/ Paralysis of the pharynx, salivation, and forced respiration/ DEATH FROM RESPIRATORY FAILURE
What are the clinical features in dogs? Puritus with paralysis of the jaws and pharynx with drooling of saliva...NO AGGRESSION (unlike Rabies)
What are the clinical features in cats? disease is very rapid so puritus may not be observed
What are 4 ways the disease can be diagnosed? (1) History and clinical signs. (2) Virus isolation. (3) Fluorescent antibody staining of frozen tissue sections (brain and tonsils). (4) Detection of Ab by serum neutralization, ELISA, and latex agglutination testss
T/F. Vaccines do not prevent infection of the establishment of latent infection by the wild-type virus. TRUE
Define: Gene-deleted vaccine This was the first genetically attenuated vaccine in Vet Med. It is a pseudorabies vaccine in which both the thymidine kinase gene and a glycoprotein gene have been removed
Created by: lkollmeier