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CIA
Circoviridae
| Question | Answer |
|---|---|
| What does CIA stand for? | Chicken Infectious Anemia |
| What are three characteristics of this disease? | (1)Growth Retardation; (2)Aplastic anemia; (3)generalize lymphoid depletion |
| Is this disease zoonotic? | NO! |
| What age groups of chickens does disease occur in? | less than 3 weeks of age; infection but NO disease can occur in other age groups |
| What is the mode of transmission? | Fecal-oral |
| How does vertical transmission occur? | 1-3 weeks viremic period following infection of antibody-negative breeder hens |
| Infection of the virus is followed by.... | VIREMIA |
| What are the principal target cells of this virus? What happens to the cell when the virus invades them? | Precursor T cells in the thymus and hemocytoblasts in the bone marrow; Apoptosis by a virus encoded protein called APOPTIN |
| There is immunosuppresion and anemia. This is due to the atrophy of the....pale....and hemorrhages in... | Thymus and less commonly the bursa of Fabricius. Bone marrow. Skeletal and subcutaneous tissue. |
| What are three clinical signs that chicks show? | anorexia, paleness, and a depressed weight gain |
| Mortality range | 10-50% |
| Are there survivors? | Yes...they recover slowly from the disease |
| How are viral antigen detected? How are antibodies detected? | PCR. ELISA and IFA. |
| How can you control this virus? | PASSIVE IMMUNITY is key!! MLV vaccines are available to vaccinate antibody-negative breeder hens prior to the start of egg production...this prevents transovarian transmission |
Created by:
lkollmeier
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