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What does CIA stand for? Chicken Infectious Anemia
What are three characteristics of this disease? (1)Growth Retardation; (2)Aplastic anemia; (3)generalize lymphoid depletion
Is this disease zoonotic? NO!
What age groups of chickens does disease occur in? less than 3 weeks of age; infection but NO disease can occur in other age groups
What is the mode of transmission? Fecal-oral
How does vertical transmission occur? 1-3 weeks viremic period following infection of antibody-negative breeder hens
Infection of the virus is followed by.... VIREMIA
What are the principal target cells of this virus? What happens to the cell when the virus invades them? Precursor T cells in the thymus and hemocytoblasts in the bone marrow; Apoptosis by a virus encoded protein called APOPTIN
There is immunosuppresion and anemia. This is due to the atrophy of the....pale....and hemorrhages in... Thymus and less commonly the bursa of Fabricius. Bone marrow. Skeletal and subcutaneous tissue.
What are three clinical signs that chicks show? anorexia, paleness, and a depressed weight gain
Mortality range 10-50%
Are there survivors? Yes...they recover slowly from the disease
How are viral antigen detected? How are antibodies detected? PCR. ELISA and IFA.
How can you control this virus? PASSIVE IMMUNITY is key!! MLV vaccines are available to vaccinate antibody-negative breeder hens prior to the start of egg production...this prevents transovarian transmission
Created by: lkollmeier