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inmunologia ac T3

QuestionAnswer
Que son los anticuerpos Proteinas plasmaticas producidos por Linfocitos B en respuesta a una infeccion (antigeno). Son especifico por cada antigeno
Funciones anticuerpo Reconocimiento y efectora
Funcion de reconocimiento Union a antigeno. Region N terminal de la molecula
Funcion efectora Anticuerpos se unen a receptores en distintas celulas del sistema inmune. Se lleva a cabo en la region C-terminal
Cadenas H o pesada Cadenas polipetidicas de alto peso molecular se unen mediante puentes disulfuro en una region llamada region bisagra
Cadena L o ligeras Se unen a cada cadena H hacia el extremo N-terminal mediante puentes disulfuro, formando los brazos del anticuerpo
Isotipos Variación determinados por la cadena pesada, afecta la función. Diferencias en contenido en azucar, longitud de la cadena, existencia o ausencia de la region bisagra y el numero de puente disulfuro
Diferentes isotipos IgM IgA1, A2 IgD IgE IgG1 2 3 et 4
Quien puede producir los subisotipos Todos los individuos sanos de una especie
Cambio de isotipo Cada LB a lo largo de la respuesta immune podra ir variando los isotipos que producen mediante este proceso que es un proceso que viene regulado por los LT y que depende del tipo de infeccion y de citocinas que se produzcan
IgG lugar Sangre (suero) porque es la mas pequeña (monomero) puede extraversarse facilmente
IgG funcion Respuesta segundaria a patogenos Capacidad de activar complemento por la via clasica Capacidad de neutralizacion tmbien puede activar la fagocitosis y activar respuestas citotoxicas mediadas por NK Responsable de la memoria inmunologica
Created by: TalissaO
 

 



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