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DU PA DM Vir Hep

Duke PA Diagnostic Methods Viral Hepatitis

general term to describe liver inflammation hepatits
causes of hepatitis immunologic damage, toxic damage (alcohol, drugs, poisons, chemicals), infections (viral, bacterial, protozoal, fungal)
WBC in hepatitis normal to low
AST in hepatitis striking elevation early (20x normal)
ALT in hepatitis striking elevation early (20x normal)
__ often precedes the appearance of jaundice, may become incidental indicator of liver injury bilirubinuria
usually not needed for diagnosis of acute viral hepatitis, but very useful in staging chronic hepatitis C liver biopsy
the acute viral hepatitides A and E
the chronic viral hepatitides B, C, and D
Hepatitis A and E are transmitted via fecal/oral route
hepatitis B, C, and D are transmitted via percutaneous permucosal/blood/blood derived body fluids
diagnosis of acute infection by presence of IgM anti-HAV
presence of IgG anti-HAV indicates previous exposure to HAV, noninfectivity and immunity
used to be called serum hepatitis hepatitis B
first evidence of infection , persists throughout clinical illness, detection establishes infetion with HBV and implies infectivity HBsAg
appears after clearance of HBsAg and after successful vaccination against Hep B, detection signals recovery from HBV infection, noninfectivity and immunity anti-HBs
appears soon after HBsAg, before anti-HBs, presecne with acute hepatitis symptoms indicate acute Hep B, persists for 3-6 months Anti-HBc IgM
Created by: bwyche