Busy. Please wait.
Log in using Clever

show password
Forgot Password?

Don't have an account?  Sign up 
Sign up using Clever

Username is available taken
show password


Make sure to remember your password. If you forget it there is no way for StudyStack to send you a reset link. You would need to create a new account.
Your email address is only used to allow you to reset your password. See our Privacy Policy and Terms of Service.

Already a StudyStack user? Log In

Reset Password
Enter the associated with your account, and we'll email you a link to reset your password.
Didn't know it?
click below
Knew it?
click below
Don't know
Remaining cards (0)
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.

  Normal Size     Small Size show me how

Pharmacology Ch.2

Romich 2nd edition "Veterinary Drug Development and Control"

Carcinogenicity the ability or tendency to produce cancer Outline the stages of drug development in the United States -Synthesis/ discovery of a new drug compound -Safety/effectiveness evaluation -Submission and review of the New Animal Drug Application (NADA) -Postmarketing Surveillance
Chronic Studies Long-term toxicity tests that run from 3 months to 24 years to prevent disastrous consequences of a drug therapy Differentiate between effective dose and lethal dose a dose can only be effective/lethal if 50% of the animals that receive have a defined reaction
Clinical Trials conducted in the target species and are done to evaluate the drug's safety and effectiveness in that species Defines margin of safety, calculate it, and understand how it relates to the appearance of toxicity signs Drug A LD50 / ED50 = Margin of Safety A wide or greater therapeutic index or margin of safety means that the drug can produce its desired effect without approaching toxicity
Effective Dose-50 the amount of the test drug causes a defined effect in 50 percent of the animals that receive it Describe how side effects related to reproduction are monitored. Reproductive tests evaluate the drug's effect on conception, fertilization, and pregnancy.
Lethal Dose-50 dose of a test drug that kills 50 percent of the animals that receive it Describe how side effects related to carcinogenicity are monitored. Carcinogenicity tests check to see if the drug causes cancerous tumors in such soft tissues as the urinary bladder or brain.
Long-Term Tests repeat of dosing and check of various organ systems for 3 to 24 months Describe how side effects related to teratogenicity are monitored. Teratogenic tests check for development of fetal defects in pregnant test animals
Long Term Toxicity Tests chronic studies
Margin of Safety therapeutic index
Parameter intensity of effect measured on a subjective scale of either 1 through 3 or through 10
Preclinical Studies a series of tests performed on laboratory animals to determine safety and effectiveness of the drug
Preliminary Studies determine if the drug produces the intended effect(s) and whether it has toxic properties
Shelf Life how long a drug remains stable and effective for use
Short-term Tests check for adverse reactions such as (seizures, paralysis, depressed breathing, depressed heart rate, and death) post drug administration
Short-term Toxicity Test tests ran within hours after drug administration to determine toxicity levels
Special Tests determine reproductive effects, carcinogenicity, and teratogenicity
Systems-oriented Screen a test of the drug's effects on a particular physiological system
Teratogenicity the capacity to cause birth defects
Therapeutic Index drug's dosage or dose that produces the desired effect with minimal or no signs of toxicity
Toxicity Evaluation determine the dose at which a drug induces organ or tissue damage that may, at a high-enough dose, result in permanent injury or death
Created by: KTHindsCC



Use these flashcards to help memorize information. Look at the large card and try to recall what is on the other side. Then click the card to flip it. If you knew the answer, click the green Know box. Otherwise, click the red Don't know box.

When you've placed seven or more cards in the Don't know box, click "retry" to try those cards again.

If you've accidentally put the card in the wrong box, just click on the card to take it out of the box.

You can also use your keyboard to move the cards as follows:

If you are logged in to your account, this website will remember which cards you know and don't know so that they are in the same box the next time you log in.

When you need a break, try one of the other activities listed below the flashcards like Matching, Snowman, or Hungry Bug. Although it may feel like you're playing a game, your brain is still making more connections with the information to help you out.

To see how well you know the information, try the Quiz or Test activity.

Pass complete!

"Know" box contains:
Time elapsed:
restart all cards