click below
click below
Normal Size Small Size show me how
Drugs, nuclei etc
Drugs
Question | Answer | |
---|---|---|
change precursor availability | L-dopa for Parkinson's disease acts | presynaptic |
inhibit nerotransmitter synthesis | alpha methyltyrosine | presynaptic |
inhibit storage of neurotransmitter | reserpine- | presynaptic |
alter release of neurotransmitter | amphetamine | presynaptic |
cholinergic nuclei | septal nuclei nucleus basalis of Meynert Striatum Cholinergic interneurons dorsal tegmental area of pontine reticular formation | |
Septal nuclei | projects via fornix to hippocampus | |
Nucleus Basalis of Meynert | projects to neocortex affected during Alzheimers | |
Striatum | contains cholinergic interneurons Degenerates in Huntington's diasease | |
Dorsal tegmental area of pontine reticular formation | projects to the thalamus involved in maintaining states of consciousness | |
Dopaminergic systems | -substantia nigra pars compacta -ventral tegmental area of reticular formation -arcuate nucleus of hypothalamus | |
substantia nigra pars compatcta | projects to striatum via nigrostriatal pathway degenerates in Parkinson's disease | |
Ventral tegmental area of reticular formation | projects to cortical and subcortical limbic nuclei Schizophrenia associated with increased dopamine production | |
arcuate nucleus of hypothalamus | projects to the infundibular portal system regulates prolactin release | |
Noradrenergic system? | Locus coeruleus lateral tegmental area of reticular formation | |
lateral tegmental area of reticular formation | involved in descending control of PAIN | |
Locus Coeruleus | projects diffusely to entire CNS involved in attention and states of arousal | |
Serotonergic system | Raphe nuclei pineal gland | |
Pineal gland | converts 5HT to melatonin regulates circadian rythms | |
Raphe Nuclei | -located all along midline of brainstem -project diffusely to entire CNS -reduced 5HT associated with depression & insomnia -reduced 5HT associated associated with depression and insomnia - increased 5HT associated with mania -descending pain contro | |
affected in Huntington's diases | striatum | |
affected in Parkinson's disease | substantia nigra pars compacta | |
affected in ventral tegmental area of reticular formation | Schizophrenia | |
involved in attention and arousal | locus coeruleus | |
Nuclei (plural) involved in descending pain control | ateral tegmental area of reticular formation raphe nuclei | |
Alzheimers drugs | aricept tacrine donepezil | |
Chronic INflammatory Demyelinating Polyradiculoneuropathy (CIDP) | autoimmune attack on myelin sheath, axon undamaged electrical activity doesn't reach NMJ--> muscle atrophy | |
Neuroma | tangled mass of poorly regenerated axons forms near site of lesion or along route of regrowth generate extreme pain due to C fibers associated with phantom limb syndrome (PLS) | |
Acoustic neuroma | tumor of CN VIII swirl of nerve sheath cells | |
riluzole | treat ALS by binding to sodium channels and inhibiting opening this inhibits Ca++ influx thus excitotoxicity seen in ALS | |
Diazepam | Gaba receptor agonist to treat anxiety (long term) | |
Lorazepam (ativan) | treat anxiety--> Gaba receptor agonist | |
Stychrine | Glycine antagonist convulsant because it inhibitis an inhibitory synapase (dysinhibition) | |
methodone | prevents heroin & morphine interaction with opoiod receptors for natural pain killers (endorphins | |
blockage of reuptake | antidepressants | presynaptic |