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Drugs, nuclei etc

Drugs

QuestionAnswer
change precursor availability L-dopa for Parkinson's disease acts presynaptic
inhibit nerotransmitter synthesis alpha methyltyrosine presynaptic
inhibit storage of neurotransmitter reserpine- presynaptic
alter release of neurotransmitter amphetamine presynaptic
cholinergic nuclei septal nuclei nucleus basalis of Meynert Striatum Cholinergic interneurons dorsal tegmental area of pontine reticular formation
Septal nuclei projects via fornix to hippocampus
Nucleus Basalis of Meynert projects to neocortex affected during Alzheimers
Striatum contains cholinergic interneurons Degenerates in Huntington's diasease
Dorsal tegmental area of pontine reticular formation projects to the thalamus involved in maintaining states of consciousness
Dopaminergic systems -substantia nigra pars compacta -ventral tegmental area of reticular formation -arcuate nucleus of hypothalamus
substantia nigra pars compatcta projects to striatum via nigrostriatal pathway degenerates in Parkinson's disease
Ventral tegmental area of reticular formation projects to cortical and subcortical limbic nuclei Schizophrenia associated with increased dopamine production
arcuate nucleus of hypothalamus projects to the infundibular portal system regulates prolactin release
Noradrenergic system? Locus coeruleus lateral tegmental area of reticular formation
lateral tegmental area of reticular formation involved in descending control of PAIN
Locus Coeruleus projects diffusely to entire CNS involved in attention and states of arousal
Serotonergic system Raphe nuclei pineal gland
Pineal gland converts 5HT to melatonin regulates circadian rythms
Raphe Nuclei -located all along midline of brainstem -project diffusely to entire CNS -reduced 5HT associated with depression & insomnia -reduced 5HT associated associated with depression and insomnia - increased 5HT associated with mania -descending pain contro
affected in Huntington's diases striatum
affected in Parkinson's disease substantia nigra pars compacta
affected in ventral tegmental area of reticular formation Schizophrenia
involved in attention and arousal locus coeruleus
Nuclei (plural) involved in descending pain control ateral tegmental area of reticular formation raphe nuclei
Alzheimers drugs aricept tacrine donepezil
Chronic INflammatory Demyelinating Polyradiculoneuropathy (CIDP) autoimmune attack on myelin sheath, axon undamaged electrical activity doesn't reach NMJ--> muscle atrophy
Neuroma tangled mass of poorly regenerated axons forms near site of lesion or along route of regrowth generate extreme pain due to C fibers associated with phantom limb syndrome (PLS)
Acoustic neuroma tumor of CN VIII swirl of nerve sheath cells
riluzole treat ALS by binding to sodium channels and inhibiting opening this inhibits Ca++ influx thus excitotoxicity seen in ALS
Diazepam Gaba receptor agonist to treat anxiety (long term)
Lorazepam (ativan) treat anxiety--> Gaba receptor agonist
Stychrine Glycine antagonist convulsant because it inhibitis an inhibitory synapase (dysinhibition)
methodone prevents heroin & morphine interaction with opoiod receptors for natural pain killers (endorphins
blockage of reuptake antidepressants presynaptic
Created by: neuroexpert
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