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IP6 Virology E2 P3

Canine Distermper & Infectious Canine Hepatitis

What genus is CDV? Morbillivirus (enveloped RNA)
What type of inclusion bodies does CDV form? intranuclear and intracytoplasmic
What is the principal resovoir host for CDV? dogs
CDV is endemic in what animal racoon
What dogs present most commonly with clinical dz? seen in 4-6 month old puppies b/c they are exposed to an infected subclinical adult dog when maternal abs are declining
How is CDV transmitted? CDV shed in all secretions/excretions. Direct contact, aerosol or droplet exposure, transplacental infection occurs
How long will the dog shed the virus? 90days
Which cells does CDV infect (4)? what does that cause Thymocytes, lymphocytes, macrophages, DCs-->causes immunosuppression
An animal with good CMI+ good humoral immune response will probably have what outcome when infected with CDV? probably have mild/subclinical infection only. These dogs can neutralize CDV and clear infection before viremia spreads to the CNS
What is the outcome for dogs with poor CMI + poor humoral immunity? get secondary viremia->widespread disemination to epithelial and CNS->full blown dz, shedding of virus in respiratory secretion, feces and urine
Systemic infection via CDV is common in what group? unvaccinated puppies
Clinical signs of systemic CDV? signs include serous-to-mucopurulent conjunctivitis, fever, and respiratory disease. The virus causes interstitial pneumonia which is often followed by secondary bacterial pneumonia. Also, GIT dz (vomiting and diarrhea, and severe inappetance
When a dog has a CNS infection with CDV what clinical signs might you see? "chewing gum fits" (myoclonic contratctions of jaw and facial mm), seizures, ataxia, weakenss, paralysis
When there is a skin infection with CDV (rare) you could see? hyperkeratosis of the nose and footpads (hard pad disease) is rare
In this form of CDV, there is a non-inflammatory demyelinating disease or neuronal necrosis that often effects young or immunosuppressed dogs Acute CDV encephalitis
In this form of encephalitis,the host immune response (inflam),not the action of the virus on the oligodendrocyte, is the cause of the demyelinating disease. Subacute to chronic encephalitis
is a chronic, progressive disease of the gray matter of the cerebral hemispheres and brainstem that is caused by persistent infection of neurons with CDV Old dog encephalitis
Most commonly used test for Dx of CDV (in addtion to signs, history and vaccination status) PCR is most commonly used test on fresh tissues. Sequencing of PCR products will allow determination of specific strain
Prevention/Control: CDV use of vaccines or natural infection produces long lasting immunity to the virus
What types of vaccines should be used in exotic spp to control CDV recombinant vaccines
T/F measles vaccine can be used to vaccinate 6-12 week old puppies for CDV true
T/F CDV is zoonotic? False
how often should you vaccinate for CDV? every year!
There are 2 strains of Canine Adenovirus what do they each cause? CAV-1->infectious canine hepatitis CAV-2->respiratory dz (implicated in kennel cough)
Hosts for CAV? dogs, coyotes, foxes, Canidae, bears
T/F in wild animals infection with CAV is usually asymptomatic true
What does acute infection with cAV cause in dogs? acute fulminant hepatitis, chronic hepatitis, ocular or respiratory disease, encephalitis, or glomerulonephritis
T/F CAV-1 is resistant to environmental inactivation and many disinfectants True-It can persist for days at room temperature, and for months at temperatures below 4C.
How is CAV transmitted? The virus is transmitted by direct contact with infected body fluids, or by contact with contaminated fomites
T/F. . Renal tubular epithelial cells remain persistently infected with virus, resulting in the shedding of virions in the urine for months post-infection true
What is the best type of immune response for clearing CAV? humoral immune response. Dogs that mount a vigorous antibody response by day 7 post-infection clear the virus and they do not have significant damage to: eyes, liver, kidneys
If the dog doesn't develop enouhg ab to prevent dz what happens? Dogs that develop a high titer of antibody that does not effectively neutralize the virus develop chronic disease -- chronic hepatitis and/or immune complex glomerulonephritis
What if the dog can't mount an antibody respnse to CAV? Dogs that fail to mount an antibody response succumb to acute hepatitis and/or disseminated intravascular coagulation (DIC).
What are the primary target cells for CAV infection? The primary targets for lethal cell damage are hepatocytes and endothelial cells
Ocular lesion seen in animals affected with CAV is called? blue eye
How do you Dx CAV-1? PCR, IHC, virus isolation
Prevention/Control of CAV-1? Dogs are vaccinated with CAV2 since it is cross protective and does not give a "blue eye" side effect like the CAV1 vaccines.
Should all dogs be vaccinated for CAV-1 (infectious canine hepatitis)? Yes. should be a core vaccine
Created by: rccola19