Cancer Word Scramble
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Question | Answer |
List the four characteristics of a benign neoplasia | No metastisase, close resemblance to tissue of origin, necrosis is rare, no invasion |
List the four characteristics of a malignant neoplasia | Metastases, invasive, necrosis is common, variable differentiation (poor resemblance to tissue of origin) |
Neoplasia can be characterised into two: | 1. Proliferation in defiance of normal constraints 2. Invade and colonise territories reserved for other cells |
Three things overactivity mutation can lead to | Mutation in coding sequence, gene amplification and chromosome rearrangement |
How does genetic instability affect cells | 1. interfere with accurate replication of genome. 2. decreases efficiency of DNA repair 3. Increases occurrence of xsome breaks and rearrangements :. unstable/abnormal karyotype |
1. Detachment | Migration of individual cells enabled |
2. Invasion | Erosion of tissue boundaries |
3. Intravasation | Access to vascular routes of dissemination |
4. Evasion of host defences | Survival against host defences |
5. Arrest | Arrest of movement by adhesion to endothelium |
6. Extravasation | Colonisation of site of metastasis |
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