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List the four characteristics of a benign neoplasia No metastisase, close resemblance to tissue of origin, necrosis is rare, no invasion
List the four characteristics of a malignant neoplasia Metastases, invasive, necrosis is common, variable differentiation (poor resemblance to tissue of origin)
Neoplasia can be characterised into two: 1. Proliferation in defiance of normal constraints 2. Invade and colonise territories reserved for other cells
Three things overactivity mutation can lead to Mutation in coding sequence, gene amplification and chromosome rearrangement
How does genetic instability affect cells 1. interfere with accurate replication of genome. 2. decreases efficiency of DNA repair 3. Increases occurrence of xsome breaks and rearrangements :. unstable/abnormal karyotype
1. Detachment Migration of individual cells enabled
2. Invasion Erosion of tissue boundaries
3. Intravasation Access to vascular routes of dissemination
4. Evasion of host defences Survival against host defences
5. Arrest Arrest of movement by adhesion to endothelium
6. Extravasation Colonisation of site of metastasis
Created by: 813890255