Transplantation Imm. Word Scramble
|
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.
Normal Size Small Size show me how
Normal Size Small Size show me how
Question | Answer |
Rejection occurs due to ? | * immune recognition and response to foreign histocompatibility antigens |
most important antigens of rejection ? | MHC..... * but there are others, so can still reject if all MHCs all line up perfectly |
What is the normal role of HLA antigens in the immune response? | * Present antigenic peptides to T cells |
HLA class 1 = ? | * HLA - A, B, C.... * also expresses B2-microglobulin.... * All are in MHC-I |
HLA class 2 = ? | * All in MHC-II.... * are HLA - DR (a/b), DP (a/b), and DQ (a/b) |
How many different HLA molecules are on the cell? | * you have both on each cell |
expression of alleles of HLA ? | * get codominance with Haplotype inheritance of MHC antigens.... * each person has 2 different halotypes for each HLA bc of two parents, but are codominantly expressed |
Hyperacute Rejection ? | * happens in minutes-hrs and is from anti-donor ABs and complement |
Acute Rejection ? | * days-weeks and is from cell mediated and humoral .... * primary activation of immune system and T-Cells recognize foreign HLA antigens.... * if Cd4+ is seen, then complement and Ab also mediates this |
Chronic Rejection ? | * time frame is months-years and MOA is unclear |
One of the top drugs for anti-rejection ? | * cyclosporine - but have to ween off c it can cause kidney issues |
Testing for Donor-Recipient Compatibility in Transplantation ? | * 1. ABO Blood typing -- 2. HLA identification (tissue typing) -- 3. Antibody Screening (reactive with HLA) -- 4. Genotyping with PCR and other molecular techniques -- 5. Crossmatching – see if recipient has preformed Abs against donor |
Why have we been using more pig transplants ? | * lack of human cadaver parts |
Hematopoietic Stem Cell Transplantation (HSCT) use and marker for them in the blood ? | * Used to treat malignancy, immunodeficiency, bone marrow defects, autoimmunity ..... * CD34 marker |
Graft-versus-host disease ? | * complication of allogeneic HSCT is graft-versus-host disease (GvHD) ..... * GvHD is caused by mature donor T cells contaminating the HSC inoculum, which can recognize HLA |
How to help GVHD ? | * help eliminate as many as those mature T-cells as possible, bc once activated, it is pretty much impossible to stop |
Acute GVHD = ? | * about 3 weeks |
Chronic GVHD = ? | * months |
Helps GVHD a lot ? | * matching of the HLA antigens |
Created by:
thamrick800
Popular Medical sets