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2VCOMPharmacology 1 Test

Enter the letter for the matching Answer
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1.
o Name the b-lactamase inhibitors:
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2.
• What are the types of microbial resistance?
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3.
• Antimicrobial spectrum fall into what categories
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4.
o Examples of antimicrobials
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5.
• Name the Narrow spectrum penicillins
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6.
• What are the targets of antibacterial drugs?
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7.
• Name some cell wall inhibitors
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8.
• Tests for MIC are what two?
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9.
• MIC stands for what?
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10.
• Why does drug fail to reach its target?
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11.
• Explain the reasons for antibiotic resistance in patients
A.
o Replication, metabolism, protein production, & certain structures i.e cell wall
B.
 Natural: Penicillin, cephalosporin C  Synthetic: Sulfamethoazole, Trimethoprim, Quinolones (ciprofloxacin, levofloxacin
C.
Competitive inhibition of b-lactamase: Aren’t antibiotics  Clavulanate  Sulbactam
D.
o Can’t penetrate cell wall/membrane due to change in structure or because of drug efflux pumps o Metabolic rxns inactivate drug o Mutations in target preclude binding of drug to target
E.
o Innate resistance:  Microbe lacks drug target of the chemotherapeutic agent. o Acquired resistance:  Microbe that has undergone a change.  Change compensates for the presence of the drug.
F.
Narrow, extended, broad
G.
The following antibiotics o b-lactam  Penicillins (and their derivatives).  Cephalosporins (four generations).  Monobactams.  Carbapenem.  (b-lactamase inhibitors). o Others  Bacitracin.  Fosfomycin.  Vancomycin
H.
Minimal inhibitory concentration
I.
Prescribing an insufficient duration, an insufficient dose, an antibiotic that is only o Prescribing when not needed. o Stopping antibiotic use as soon as symptoms disappear, Taking antibiotics without physicians supervision.
J.
Etest and Disk diffusion
K.
 Penicillin G  Penicillin V
Type the Answer that corresponds to the displayed Question.
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12.
•How do bacteria acquire resistance?
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13.
o Name the Penicillinase resistant penicillins

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Created by: VCOM2013
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