Renal2-Clin Med 3
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| Sustained proteinuria of _____ is common in glomerular disease | >1-2g/24hours
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| What are the three major syndromes of glomerular disease? | Nephritic syndrome, nephrotic syndrome, asymptomatic renal disease
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| Primary renal disease where | there are only renal abnormalities
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| Secondary renal disease where | renal disease is secondary to a systemic disease
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| Etiology of glomerular dz | Idiopathic, infection, autoimmune disease (SLE, Goodpasture's), atherosclerosis, *hypertension, *diabetes mellitus
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| Glomerularnephritis definition | Inflammation of the glomerular capillaries
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| Describe immune mediated glomerulonephritis | immune deposits along the GBM causes anti-GBM antibodies to be produced. They trigger the immune cascade. The cytokines released cause destruction of capillary and mesangium
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| Systemic hypertension and atherosclerosis can be the cause of | Chronic glomerulosclerosis
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| Primary disturbance noted in glomerulonephritis | blood in the urine
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| Malignant hypertension leads to fibrinoid necrosis of arterioles and glomeruli leading to... | Acute renal failure
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| Long-standing effects of hyperglycemia will lead to... | Thickening of the GBM
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| two mechanisms that are affected by changes in vascular resistance | Decreased perfusion leads to ischemic injury; Impairment of glomerular arterial outflow leads to intraglomerular hypertension. ultimately Acute and Chronic Tubular Interstitial Nephropathy
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| Swelling is caused by the (excess/lack of) albumin? | lack of.
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| Lab results/UA of glomerulonephritis | RBC Casts, dysmorphic RBC, proteinuria >1-2g/24hrs.
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| Benign proteinuria (<1gm/24hrs) is present in | fever, exercise, pregnancy, obesity
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| Describe the urine and patient condition in GD | urine is foamy, and patient is edematous
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| Minimal change dz excretion | children with minimal change dz excrete only albumin
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| Acute Nephritic Syndrome | Proteinuria, hematuria, pyuria, hypertension, fluid retention, gradual rise in creatinine
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| 6 types of nephritic syndrome | RPGN (Cresentic GN), Post streptococcal GN, endocarditis associated GN, Lupus nephritis, Antiglomerular basement membrane dz (Good pasture's syndrome), IgA nephropathy (Berger's Dz)
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| Rapidly Progressive Glomerular Nephritis | the Cresentic GN is a variety of RPGN with a characteristic glomerular lesion
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| Post Streptococcal GN | usu. in the pediatric patients 2-14
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| 4 types of nephrotic syndrome | Minimal change disease, membranous nephropathy, membranoproliferative GN, Focal glomerular sclerosis
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