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Renal2-Clin Med 3
| Question | Answer |
|---|---|
| Sustained proteinuria of _____ is common in glomerular disease | >1-2g/24hours |
| What are the three major syndromes of glomerular disease? | Nephritic syndrome, nephrotic syndrome, asymptomatic renal disease |
| Primary renal disease where | there are only renal abnormalities |
| Secondary renal disease where | renal disease is secondary to a systemic disease |
| Etiology of glomerular dz | Idiopathic, infection, autoimmune disease (SLE, Goodpasture's), atherosclerosis, *hypertension, *diabetes mellitus |
| Glomerularnephritis definition | Inflammation of the glomerular capillaries |
| Describe immune mediated glomerulonephritis | immune deposits along the GBM causes anti-GBM antibodies to be produced. They trigger the immune cascade. The cytokines released cause destruction of capillary and mesangium |
| Systemic hypertension and atherosclerosis can be the cause of | Chronic glomerulosclerosis |
| Primary disturbance noted in glomerulonephritis | blood in the urine |
| Malignant hypertension leads to fibrinoid necrosis of arterioles and glomeruli leading to... | Acute renal failure |
| Long-standing effects of hyperglycemia will lead to... | Thickening of the GBM |
| two mechanisms that are affected by changes in vascular resistance | Decreased perfusion leads to ischemic injury; Impairment of glomerular arterial outflow leads to intraglomerular hypertension. ultimately Acute and Chronic Tubular Interstitial Nephropathy |
| Swelling is caused by the (excess/lack of) albumin? | lack of. |
| Lab results/UA of glomerulonephritis | RBC Casts, dysmorphic RBC, proteinuria >1-2g/24hrs. |
| Benign proteinuria (<1gm/24hrs) is present in | fever, exercise, pregnancy, obesity |
| Describe the urine and patient condition in GD | urine is foamy, and patient is edematous |
| Minimal change dz excretion | children with minimal change dz excrete only albumin |
| Acute Nephritic Syndrome | Proteinuria, hematuria, pyuria, hypertension, fluid retention, gradual rise in creatinine |
| 6 types of nephritic syndrome | RPGN (Cresentic GN), Post streptococcal GN, endocarditis associated GN, Lupus nephritis, Antiglomerular basement membrane dz (Good pasture's syndrome), IgA nephropathy (Berger's Dz) |
| Rapidly Progressive Glomerular Nephritis | the Cresentic GN is a variety of RPGN with a characteristic glomerular lesion |
| Post Streptococcal GN | usu. in the pediatric patients 2-14 |
| 4 types of nephrotic syndrome | Minimal change disease, membranous nephropathy, membranoproliferative GN, Focal glomerular sclerosis |
Created by:
Colter
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