Cytokines for exam
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| IL-1 is secreted by? | Monocytes/activated macrophages
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| IL-2 is secreted by? | CD4+ T-cells (Th-1)
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| IL-4 is secreted by? | CD4+ T-cells (Th-2)
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| IL-5 is secreted by? | Th-2
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| IL-6 is secreted by? | T cells (Th-2) and macrophages
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| IL-7 is secreted by? | Hassel Corpuscles,
Thymic cortical epithelial cells,
Bone Marrow Stromal
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| IL-8 is secreted by? | Activated macrophages
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| IL-12 is secreted by? | Activated macrophages
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| IL-13 is secreted by? | TH-2
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| IFN-alpha is secreted by? | All cells; higher levels in monocytes and fibroblasts
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| IFN-Beta is secreted by? | All cells; higher levels in monocytes and fibroblasts
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| IFN-Gamma is secreted by? | All cells but main source are T cells (CD4 Th1) and NK cells
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| TNFα is secreted by? | Many cell types especially activated macrophages
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| TNFβ is secreted by? | T (Th-1)and B cells
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| CC are secreted by? | Many cell types (neutrophils, B and T cells, etc)
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| CXC are secreted by? | Many cell types (neutrophils, B and T cells, etc)
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| Effects of IL-1? | Fever/pyrogen,
Induction of adhesion proteins & APCs,
Increase vascular permeability,
Autocrine (on macrophage and monocytes),
T-cell activation & helps it secrete IL2,
B cell proliferation
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| Effects of IL-2? | Autocrine (on CD4),
“Growth factor” of various cells (need Ag),
Prolif/diff of T,B, or NK cells,
Part of inflammatory subset secreted by Th1
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| Effects of IL-4? | Critical for B cell activation and prolif,
Class switching (IgM to IgG,A,E..),
Induces Naïve CD4+ into Th-2,
Part of helper subset secreted by Th2
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| Effects of IL-5? | Part of helper subset secreted by Th2,
Important for the activation of eosinophils
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| Effects of IL-6? | Fever, B-cell proliferation,
Part of helper subset secreted by Th2,
Helps produce MBP
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| Effects of IL-7? | T/B cell prolif during development,
Needed in culture systems (outside Thymus)
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| Effects of IL-8? | Chemotactic for neutrophils,
Increase vascular permeability
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| Effects of IL-10? | Induces Naïve CD4+ into Th-2
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| Effects of IL-12? | Activates NK cells,
Induces Naïve CD4+ into Th-1
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| Effects of IL-13? | B-cell proliferation,
Part of helper subset secreted by Th2
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| Effects of IFN-alpha? | Induce antiviral state (all),
Activate NK cells (all)
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| Effects of IFN-Beta? | Induce antiviral state (all),
Activate NK cells (all)
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| Effects of IFN-gamma? | Induce antiviral state (all),
Activate NK cells (all),
Stimulate macrophage activation,
Class switching IgG (subclass 2 &3),
Part of inflammatory subset secreted by Th1
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| Effects of TNFα? | Fever,
Chemotactic,
Increase vascular permeability,
Directly kill tumor cells,
Activate moncytes/macrophages,
Expression of adhesion molecules
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| Effects of TNFβ? | Directly kill tumor cells,
Activate moncytes/macrophages,
Expression of adhesion molecules,
Part of inflammatory subset secreted by Th1
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| Effects of TGFβ? | Induces Naïve CD4+ into Th-1,
a T-cell factor
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| Effects of CC? | Attract monocytes and T cells
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| Effects of CXC? | Attract neutrophils (same as IL8)
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