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Immunology Cytokines

Cytokines for exam

QuestionAnswer
IL-1 is secreted by? Monocytes/activated macrophages
IL-2 is secreted by? CD4+ T-cells (Th-1)
IL-4 is secreted by? CD4+ T-cells (Th-2)
IL-5 is secreted by? Th-2
IL-6 is secreted by? T cells (Th-2) and macrophages
IL-7 is secreted by? Hassel Corpuscles, Thymic cortical epithelial cells, Bone Marrow Stromal
IL-8 is secreted by? Activated macrophages
IL-12 is secreted by? Activated macrophages
IL-13 is secreted by? TH-2
IFN-alpha is secreted by? All cells; higher levels in monocytes and fibroblasts
IFN-Beta is secreted by? All cells; higher levels in monocytes and fibroblasts
IFN-Gamma is secreted by? All cells but main source are T cells (CD4 Th1) and NK cells
TNFα is secreted by? Many cell types especially activated macrophages
TNFβ is secreted by? T (Th-1)and B cells
CC are secreted by? Many cell types (neutrophils, B and T cells, etc)
CXC are secreted by? Many cell types (neutrophils, B and T cells, etc)
Effects of IL-1? Fever/pyrogen, Induction of adhesion proteins & APCs, Increase vascular permeability, Autocrine (on macrophage and monocytes), T-cell activation & helps it secrete IL2, B cell proliferation
Effects of IL-2? Autocrine (on CD4), “Growth factor” of various cells (need Ag), Prolif/diff of T,B, or NK cells, Part of inflammatory subset secreted by Th1
Effects of IL-4? Critical for B cell activation and prolif, Class switching (IgM to IgG,A,E..), Induces Naïve CD4+ into Th-2, Part of helper subset secreted by Th2
Effects of IL-5? Part of helper subset secreted by Th2, Important for the activation of eosinophils
Effects of IL-6? Fever, B-cell proliferation, Part of helper subset secreted by Th2, Helps produce MBP
Effects of IL-7? T/B cell prolif during development, Needed in culture systems (outside Thymus)
Effects of IL-8? Chemotactic for neutrophils, Increase vascular permeability
Effects of IL-10? Induces Naïve CD4+ into Th-2
Effects of IL-12? Activates NK cells, Induces Naïve CD4+ into Th-1
Effects of IL-13? B-cell proliferation, Part of helper subset secreted by Th2
Effects of IFN-alpha? Induce antiviral state (all), Activate NK cells (all)
Effects of IFN-Beta? Induce antiviral state (all), Activate NK cells (all)
Effects of IFN-gamma? Induce antiviral state (all), Activate NK cells (all), Stimulate macrophage activation, Class switching IgG (subclass 2 &3), Part of inflammatory subset secreted by Th1
Effects of TNFα? Fever, Chemotactic, Increase vascular permeability, Directly kill tumor cells, Activate moncytes/macrophages, Expression of adhesion molecules
Effects of TNFβ? Directly kill tumor cells, Activate moncytes/macrophages, Expression of adhesion molecules, Part of inflammatory subset secreted by Th1
Effects of TGFβ? Induces Naïve CD4+ into Th-1, a T-cell factor
Effects of CC? Attract monocytes and T cells
Effects of CXC? Attract neutrophils (same as IL8)
Created by: fportugal