cytokines
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| IL-1 Source | Mphage, monocyte, DCs
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| IL-1 Effect | inflammation in innate immunity, get endothelium to express E and P selectin
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| IL-2 Source | Activated Tcells (4 and 8)
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| IL-2 targets | Tcells (4 and 8)
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| IL-2 Effect | Stim Tcell prolif, NK/Bcell diff and prolif
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| IL-3 Source | CD4 Th1 cells, eosinophils, mast cells
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| IL-3 Effect | Expansion of immature blood cell progenitors
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| IL-4 Source | CD4 Th2 cells
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| IL-4 targets | other Th2, Bcells
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| IL-4 effect | Th2 diff, IgE production, Bcell prolif, inhib Th1 mediated immunity
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| IL-5 source | CD4Th2, activated mast cells
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| IL-5 target | Bcells, eosinophils
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| IL-5 effect | Isotype switch, eos growth and diff
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| IL-6 source | Mphage, monocytes, DCs
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| IL-6 target | liver Bcells
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| IL-6 effect | Stim acute phase proteins, plasma Bcell growth
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| IL-8 source | Mphage, monocytes, DCs
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| IL-8 target | Nphils
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| IL-8 effect | Call in other Nphils
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| IL-10 source | CD4 Th2 cells
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| IL-10 Effect | Isotype switch, Inhib Mphage and Th1cells
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| IL-12 source | Mphage, Monocytes, DCs
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| IL-12 target | NKcells, Tcells
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| IL-12 effect | activate NK, prommote Th1 activity
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| IL-13 source | CD4 Th2
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| IL-13 target | Bcells
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| IL-13 effect | stim IgE production
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| PAF source | Mast cells/eos
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| PAF target | Nphils
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| PAF effect | Attracts Nphils
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| MCP-1 source | CD4 Th1 cells
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| MCP-1 target | Mphage, Monocytes, DCs
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| MCP-1 effect | Recruit Mphages
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| TNF-a source | Mphage, monocyte, DCs, act CD4Th1 cells
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| TNF-a target | Endothelium, Nphils, monocytes, Mphages
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| TNF-a effect | vasc. perm., CAM expression, thrombosis, vasodilation
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| TNF-B source | CD4 Th2 cells
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| TNF-B target | Bcells
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| TNF-B effect | Isotype switching
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| INF-gamma source | CD4 Th1 cells, NK cells
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| IFN gamma target | Mphate, Bcells
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| IFN gamma effect | Act. Mphage, Isotype switch
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| GM-CSF source | CD4 Th1/Th2 cells
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| GM-CSF target | lymphocyte progenitors
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| TBF-B source | CD4 Th2, Mphage, monocytes, DCs
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| TBF-B target | Tcells, Mphage
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| TBF-B effect | Inhib Tcells, Mphage, inflammatory cytokines
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| MIF source | CD4Th1 cells
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| MIF target | Mphage
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| MIF effect | Inhib Mphage migration from site
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| CCL13 source | lymph nodes
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| CCL13 target | Bcells, eosinophils
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| CCL13 effect | attract Bcells
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| CCL17/27 source | skin
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| CCL17/27 target | Tcells
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| CCL17/27 effect | Attract Tcells
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| CCL 18 source | DCs
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| CCL18 target | Naive Tcells
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| CCL18 effect | attract naive Tcells to lymph nodes
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| CCL 19/21 source | lymph nodes, DCs
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| CCL19/21 target | Tcells
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| CCL19/21 effect | attract Tcells
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| CCL25/28 source | lamina propria
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| CCL25/28 target | Tcells
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| CCL25/28 effect | Attract Tcells to gut
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| XCL1 source | thymus
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| XCL1 target | "future" thymocytes
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| XCL1 effect | attract prethymocytes to thymus
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