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cytokines
| Question | Answer |
|---|---|
| IL-1 Source | Mphage, monocyte, DCs |
| IL-1 Effect | inflammation in innate immunity, get endothelium to express E and P selectin |
| IL-2 Source | Activated Tcells (4 and 8) |
| IL-2 targets | Tcells (4 and 8) |
| IL-2 Effect | Stim Tcell prolif, NK/Bcell diff and prolif |
| IL-3 Source | CD4 Th1 cells, eosinophils, mast cells |
| IL-3 Effect | Expansion of immature blood cell progenitors |
| IL-4 Source | CD4 Th2 cells |
| IL-4 targets | other Th2, Bcells |
| IL-4 effect | Th2 diff, IgE production, Bcell prolif, inhib Th1 mediated immunity |
| IL-5 source | CD4Th2, activated mast cells |
| IL-5 target | Bcells, eosinophils |
| IL-5 effect | Isotype switch, eos growth and diff |
| IL-6 source | Mphage, monocytes, DCs |
| IL-6 target | liver Bcells |
| IL-6 effect | Stim acute phase proteins, plasma Bcell growth |
| IL-8 source | Mphage, monocytes, DCs |
| IL-8 target | Nphils |
| IL-8 effect | Call in other Nphils |
| IL-10 source | CD4 Th2 cells |
| IL-10 Effect | Isotype switch, Inhib Mphage and Th1cells |
| IL-12 source | Mphage, Monocytes, DCs |
| IL-12 target | NKcells, Tcells |
| IL-12 effect | activate NK, prommote Th1 activity |
| IL-13 source | CD4 Th2 |
| IL-13 target | Bcells |
| IL-13 effect | stim IgE production |
| PAF source | Mast cells/eos |
| PAF target | Nphils |
| PAF effect | Attracts Nphils |
| MCP-1 source | CD4 Th1 cells |
| MCP-1 target | Mphage, Monocytes, DCs |
| MCP-1 effect | Recruit Mphages |
| TNF-a source | Mphage, monocyte, DCs, act CD4Th1 cells |
| TNF-a target | Endothelium, Nphils, monocytes, Mphages |
| TNF-a effect | vasc. perm., CAM expression, thrombosis, vasodilation |
| TNF-B source | CD4 Th2 cells |
| TNF-B target | Bcells |
| TNF-B effect | Isotype switching |
| INF-gamma source | CD4 Th1 cells, NK cells |
| IFN gamma target | Mphate, Bcells |
| IFN gamma effect | Act. Mphage, Isotype switch |
| GM-CSF source | CD4 Th1/Th2 cells |
| GM-CSF target | lymphocyte progenitors |
| TBF-B source | CD4 Th2, Mphage, monocytes, DCs |
| TBF-B target | Tcells, Mphage |
| TBF-B effect | Inhib Tcells, Mphage, inflammatory cytokines |
| MIF source | CD4Th1 cells |
| MIF target | Mphage |
| MIF effect | Inhib Mphage migration from site |
| CCL13 source | lymph nodes |
| CCL13 target | Bcells, eosinophils |
| CCL13 effect | attract Bcells |
| CCL17/27 source | skin |
| CCL17/27 target | Tcells |
| CCL17/27 effect | Attract Tcells |
| CCL 18 source | DCs |
| CCL18 target | Naive Tcells |
| CCL18 effect | attract naive Tcells to lymph nodes |
| CCL 19/21 source | lymph nodes, DCs |
| CCL19/21 target | Tcells |
| CCL19/21 effect | attract Tcells |
| CCL25/28 source | lamina propria |
| CCL25/28 target | Tcells |
| CCL25/28 effect | Attract Tcells to gut |
| XCL1 source | thymus |
| XCL1 target | "future" thymocytes |
| XCL1 effect | attract prethymocytes to thymus |
Created by:
glavik
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