taste + gustation along with smell
Quiz yourself by thinking what should be in
each of the black spaces below before clicking
on it to display the answer.
Help!
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| OBP | Oderant binding protein which is secreted by basal cells in the olfactory epithelium along with mucus
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| Where is the oderant receptor | they are expressed by cilia in the olfactory epithelium
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| Oderant receptors bind | many drugs---typically will bind a certain type of chemical sequence etc. So a smell is a combination of firing caused by multiple types of OR
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| olfactory neurons | are the only neural cells that are constantly replaced (eg they are exposed to odorants and toxins that may damage them)
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| Anosmia | you get specific anosmias if you knock-out and a specific ORN(OBP), but general anosmiaif you impair the CNG channel and cAMP fluxes caused by the Gprotein linked receptors
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| what are the five taste modalities | sweet, bitter, umami, sour, salty
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| Sweet and Umani | T1R1, T1R2, T1R3
mM range affinity. These receptors produce "attraction to " nutrient
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| Bitter receptors | T2 (30 receptor types)--- since avoiding poisons is important they must bind toxic stimuli with high affinity (micromolar). Activation of this pathway produces avoidance of food
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| T1 vs T2 | They have the same downstream transduction pathway, but you are able to tell whether a chemical is good or bad because T1 and T2 are strictly segregated in different cells
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| Tasting hot/spicy etc... | touch receptors that are activated by cold/menthol, and heat capsaicin respectively.
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