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olfact + taste

taste + gustation along with smell

OBP Oderant binding protein which is secreted by basal cells in the olfactory epithelium along with mucus
Where is the oderant receptor they are expressed by cilia in the olfactory epithelium
Oderant receptors bind many drugs---typically will bind a certain type of chemical sequence etc. So a smell is a combination of firing caused by multiple types of OR
olfactory neurons are the only neural cells that are constantly replaced (eg they are exposed to odorants and toxins that may damage them)
Anosmia you get specific anosmias if you knock-out and a specific ORN(OBP), but general anosmiaif you impair the CNG channel and cAMP fluxes caused by the Gprotein linked receptors
what are the five taste modalities sweet, bitter, umami, sour, salty
Sweet and Umani T1R1, T1R2, T1R3 mM range affinity. These receptors produce "attraction to " nutrient
Bitter receptors T2 (30 receptor types)--- since avoiding poisons is important they must bind toxic stimuli with high affinity (micromolar). Activation of this pathway produces avoidance of food
T1 vs T2 They have the same downstream transduction pathway, but you are able to tell whether a chemical is good or bad because T1 and T2 are strictly segregated in different cells
Tasting hot/spicy etc... touch receptors that are activated by cold/menthol, and heat capsaicin respectively.
Created by: 16310914