CM- Neuro -11- Parkinsons disease
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| Pt is loosing neurons in the substantia nigra what disease are they likely to suffer from | Parkinson's disease
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| What is a classic pathologic hallmark in parkinson's disease | lewy bodies
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| what are the classic s/sx of parkinson's disease | Rigidity, Imbalance/postural, resting tremor, bradykinesia
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| What race has highest incidence of parkinson's disease | Caucasian
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| Pt has pill rolling tremor what are they likely suffering from | Parkinson's disease
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| T/F parkinsons tremors still appear while pt is sleeping | F
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| What will be the clinical presentation of rigidity in parkinson's disease | increased muscle tone (cogwheel) and increased resistance to passive movement
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| Pt presents to your office with a stooped posture they don't move their arms while they walk and are taking small shuffling steps they seem to pause occasionally while walking what are they suffering from | parkinson's disease
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| What are some factors for dx of parkinsons disease | comprehensive hx and physical with asymmetric signs, resting tremors and good response to L-Dopa
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| T/F Parkinsons disease usually manifests with symmetric signs | F usually asymmetric signs
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| T/F parkinsons does not have resting tremors only action tremors | F Resting tremors
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| T/F the Cure for parkinsons disease is administration of L-Dopa | F it is only a tx there are no cures the disease will continue to progress L-Dopa just restores some function temporarily
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| What drugs should you avoid at all possible in a pt with parkinsons | Antiemetics, and MAOIs and Methyldopa
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| Why would you prescribe seligiline in parkinsons disease | delays need for l-dopa can provide some neuroprotection and blocks metabolism of dopamine and doesn't worsen disease symptoms
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| What is a negative effect of taking L-Dopa | it may actaully accelerate disease progression and can caug N/V, hallucinations, orthostatic hypotension and choreiform movement
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| What drugs can you prescribe to tx parkinsons disease besides L-Dopa | Dopamine agonists such as bromocriptine, ropinarole, pramipexole; Amantandine (symmetrel); Anticholinergics such as benzotropine, trihexphenidyl and diphenhydramine to tx dystonia
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| T/F COMT inhibitors can be given as monotherapy for parkinsons disease | F only effective when given with L-dopa
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