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Session 4 CM Neur-11

CM- Neuro -11- Parkinsons disease

Pt is loosing neurons in the substantia nigra what disease are they likely to suffer from Parkinson's disease
What is a classic pathologic hallmark in parkinson's disease lewy bodies
what are the classic s/sx of parkinson's disease Rigidity, Imbalance/postural, resting tremor, bradykinesia
What race has highest incidence of parkinson's disease Caucasian
Pt has pill rolling tremor what are they likely suffering from Parkinson's disease
T/F parkinsons tremors still appear while pt is sleeping F
What will be the clinical presentation of rigidity in parkinson's disease increased muscle tone (cogwheel) and increased resistance to passive movement
Pt presents to your office with a stooped posture they don't move their arms while they walk and are taking small shuffling steps they seem to pause occasionally while walking what are they suffering from parkinson's disease
What are some factors for dx of parkinsons disease comprehensive hx and physical with asymmetric signs, resting tremors and good response to L-Dopa
T/F Parkinsons disease usually manifests with symmetric signs F usually asymmetric signs
T/F parkinsons does not have resting tremors only action tremors F Resting tremors
T/F the Cure for parkinsons disease is administration of L-Dopa F it is only a tx there are no cures the disease will continue to progress L-Dopa just restores some function temporarily
What drugs should you avoid at all possible in a pt with parkinsons Antiemetics, and MAOIs and Methyldopa
Why would you prescribe seligiline in parkinsons disease delays need for l-dopa can provide some neuroprotection and blocks metabolism of dopamine and doesn't worsen disease symptoms
What is a negative effect of taking L-Dopa it may actaully accelerate disease progression and can caug N/V, hallucinations, orthostatic hypotension and choreiform movement
What drugs can you prescribe to tx parkinsons disease besides L-Dopa Dopamine agonists such as bromocriptine, ropinarole, pramipexole; Amantandine (symmetrel); Anticholinergics such as benzotropine, trihexphenidyl and diphenhydramine to tx dystonia
T/F COMT inhibitors can be given as monotherapy for parkinsons disease F only effective when given with L-dopa
Created by: smaxsmith