Onc-oncogenes and suppressors
Quiz yourself by thinking what should be in
each of the black spaces below before clicking
on it to display the answer.
Help!
|
|
||||
|---|---|---|---|---|---|
| abl | CML, oncogene
🗑
|
||||
| c-myc | burkitt's lymphoma, oncogene
🗑
|
||||
| bcl-2 | follicular and undifferentiated lymphoma (inhibits apoptosis), oncogene
🗑
|
||||
| erb-B2 | breast, ovarian, and gastric carcinoma, oncogene
🗑
|
||||
| ras | colon carcinoma, oncogene
🗑
|
||||
| L-myc | Lung tumor, oncogene
🗑
|
||||
| N-myc | Neuroblastoma
🗑
|
||||
| ret | multiple endocrine neoplasia (MEN) types I and II, oncogene
🗑
|
||||
| Rb | chrom 13q, tumor suppressor, retinoblastoma, osteosarcoma. suppresses G1 -->S by inactivating EF2
🗑
|
||||
| BRCA 1 and 2 | 17q, 13q. tumor suppresor gene, breast and ovarian cancer
🗑
|
||||
| p53 | 17p, tumor suppressor gene, activates apoptosis, most human cancers, Li-Fraumeni syndrome
🗑
|
||||
| p16 | 9p, tumor suppressor gene, melanoma
🗑
|
||||
| APC | 5q, tumor suppressor gene, colorectal cancer
🗑
|
||||
| WT1 | 11q, Wilms' tumor, tumor suppressor gene
🗑
|
||||
| NF1 | 17q, tumor suppressor gene, Neurofibromatosis type 1
🗑
|
||||
| NF2 | 22q, tumor suppressor gene, Neurofibromatosis type 2
🗑
|
||||
| DPC | 18q, tumor suppressor gene, pancreatic cancer
🗑
|
||||
| DCC | 18q, tumor suppressor gene, colon cancer
🗑
|
||||
| PSA (prostatic acid phosphatase) | prostate specific antigen, prostatic carcinoma, used for screening
🗑
|
||||
| CEA | carcinoembyronic antigen. very nonspecific but make by about 70% of colorectal and pancreatic cancers; also produced by gastric and breast carcinomas
🗑
|
||||
| a-fetoprotein | fetus (normal). hepatocellular carcinomas. nenseminomatous germ cell tumors of the testis (eg yolk sac tumor)
🗑
|
||||
| B-hCG | Hyaditidorm mole, choriocarcinoma, gestational trophoblastic tumors
🗑
|
||||
| CA-125 | ovarian, malignant epithelial tumors
🗑
|
||||
| S-100 | melanoma, neural tumors, astrocytoma
🗑
|
||||
| alkaline phosphatase | metastases to bone, obstructive biliary disease, Paget's disease of bone
🗑
|
||||
| bombesin | neuroblastoma, lung and gastric cancer
🗑
|
||||
| TRAP | Tartrate-resistant acid phosphatase. hair cell leukemia, a B cell neoplasm
🗑
|
||||
| t(9;22) | Philadelphia chromosome, CML (bcr-abl hybrid)
🗑
|
||||
| t(8;14) | Burkitt's lymphoma, c-myc activation
🗑
|
||||
| t(14;18) | follicular lymphoma (bcl-2 activation)
🗑
|
||||
| t(15;17) | M3 type of AML (responsive to all trans retinoic acid). translocation of retinoic acid receptor
🗑
|
||||
| t(11;22) | Ewing's sarcoma
🗑
|
||||
| t(11;14) | Mantle cell lymphoma. overexpression of cyclins rushes cell through cycle and results in hyperproliferation.
🗑
|
||||
| Hodgkin's therapy ABVD | adriamycin (doxorubicin), bleomycin, vincristine, dexamethasone
🗑
|
||||
| Hodgkin's therapy MOPP | mustard, oncovin (vincristine), procarbazine, prednisone
🗑
|
||||
| T cell marker | CD 1-8
🗑
|
||||
| B cell marker | CD 10, 19-23
🗑
|
||||
| Mono, mac marker | CD 13, 14, 15, 33
🗑
|
||||
| Stem cell | CD 34
🗑
|
||||
| ALL marker | CD 45
🗑
|
||||
| NK marker | CD 16, 56
🗑
|
||||
| B Cell ALL marker | CD 10, 19, 20
🗑
|
||||
| T Cell ALL Marker | CD1 and Pan T
🗑
|
||||
| CLL marker | CD 5, 23
🗑
|
Review the information in the table. When you are ready to quiz yourself you can hide individual columns or the entire table. Then you can click on the empty cells to reveal the answer. Try to recall what will be displayed before clicking the empty cell.
To hide a column, click on the column name.
To hide the entire table, click on the "Hide All" button.
You may also shuffle the rows of the table by clicking on the "Shuffle" button.
Or sort by any of the columns using the down arrow next to any column heading.
If you know all the data on any row, you can temporarily remove it by tapping the trash can to the right of the row.
To hide a column, click on the column name.
To hide the entire table, click on the "Hide All" button.
You may also shuffle the rows of the table by clicking on the "Shuffle" button.
Or sort by any of the columns using the down arrow next to any column heading.
If you know all the data on any row, you can temporarily remove it by tapping the trash can to the right of the row.
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.
Normal Size Small Size show me how
Normal Size Small Size show me how
Created by:
rocktheboat4
Popular Medical sets