Help
Options
Didn't know it?
click below
click below
Knew it?
click below
click below
Don't Know
Remaining cards (0)
Know
retry
shuffle
restart
0:00
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.
Normal Size Small Size show me how
Normal Size Small Size show me how
Onc
Onc-oncogenes and suppressors
| Question | Answer |
|---|---|
| abl | CML, oncogene |
| c-myc | burkitt's lymphoma, oncogene |
| bcl-2 | follicular and undifferentiated lymphoma (inhibits apoptosis), oncogene |
| erb-B2 | breast, ovarian, and gastric carcinoma, oncogene |
| ras | colon carcinoma, oncogene |
| L-myc | Lung tumor, oncogene |
| N-myc | Neuroblastoma |
| ret | multiple endocrine neoplasia (MEN) types I and II, oncogene |
| Rb | chrom 13q, tumor suppressor, retinoblastoma, osteosarcoma. suppresses G1 -->S by inactivating EF2 |
| BRCA 1 and 2 | 17q, 13q. tumor suppresor gene, breast and ovarian cancer |
| p53 | 17p, tumor suppressor gene, activates apoptosis, most human cancers, Li-Fraumeni syndrome |
| p16 | 9p, tumor suppressor gene, melanoma |
| APC | 5q, tumor suppressor gene, colorectal cancer |
| WT1 | 11q, Wilms' tumor, tumor suppressor gene |
| NF1 | 17q, tumor suppressor gene, Neurofibromatosis type 1 |
| NF2 | 22q, tumor suppressor gene, Neurofibromatosis type 2 |
| DPC | 18q, tumor suppressor gene, pancreatic cancer |
| DCC | 18q, tumor suppressor gene, colon cancer |
| PSA (prostatic acid phosphatase) | prostate specific antigen, prostatic carcinoma, used for screening |
| CEA | carcinoembyronic antigen. very nonspecific but make by about 70% of colorectal and pancreatic cancers; also produced by gastric and breast carcinomas |
| a-fetoprotein | fetus (normal). hepatocellular carcinomas. nenseminomatous germ cell tumors of the testis (eg yolk sac tumor) |
| B-hCG | Hyaditidorm mole, choriocarcinoma, gestational trophoblastic tumors |
| CA-125 | ovarian, malignant epithelial tumors |
| S-100 | melanoma, neural tumors, astrocytoma |
| alkaline phosphatase | metastases to bone, obstructive biliary disease, Paget's disease of bone |
| bombesin | neuroblastoma, lung and gastric cancer |
| TRAP | Tartrate-resistant acid phosphatase. hair cell leukemia, a B cell neoplasm |
| t(9;22) | Philadelphia chromosome, CML (bcr-abl hybrid) |
| t(8;14) | Burkitt's lymphoma, c-myc activation |
| t(14;18) | follicular lymphoma (bcl-2 activation) |
| t(15;17) | M3 type of AML (responsive to all trans retinoic acid). translocation of retinoic acid receptor |
| t(11;22) | Ewing's sarcoma |
| t(11;14) | Mantle cell lymphoma. overexpression of cyclins rushes cell through cycle and results in hyperproliferation. |
| Hodgkin's therapy ABVD | adriamycin (doxorubicin), bleomycin, vincristine, dexamethasone |
| Hodgkin's therapy MOPP | mustard, oncovin (vincristine), procarbazine, prednisone |
| T cell marker | CD 1-8 |
| B cell marker | CD 10, 19-23 |
| Mono, mac marker | CD 13, 14, 15, 33 |
| Stem cell | CD 34 |
| ALL marker | CD 45 |
| NK marker | CD 16, 56 |
| B Cell ALL marker | CD 10, 19, 20 |
| T Cell ALL Marker | CD1 and Pan T |
| CLL marker | CD 5, 23 |
Created by:
rocktheboat4
Popular Medical sets