DD
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each of the black spaces below before clicking
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| O2 requirement of Clost | anaerobic (canned food)
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| Fn of clostridium botulism | blocks ACh release (floppy)
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| how do you treat botulism | antitoxin, intubation, hyparbaric O2
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| how does infantile botulism present | constipation 2-3 days then trouble swollowing
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| C. tetani has what exotoxin | tetanospasmin
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| mechanism of tetanus | prevents GABA and Glycine release
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| two characteristic findings of tetanus | Trismus, and Ridus sardonicus
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| how do you treat tetanus | neutralize, immunization boster, clean wound, abx, supportive care
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| C. perfringus is normally found? | GI and vagina
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| how common are leukocytes with gas gangrene | none
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| what types of C. perfringus causes gangreen | types A-E
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| where does C. perfringus grow with cellulitis | in necrotic tissue
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| how can you tell it is cullulitis of c. perfringus | crackling texture
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| how does clostridium mycronecrosis happen | trauma from spore innoculation into the muscle
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| what will you see on ct of c. perfringus infection of the muscle | gas pockets
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| what gross finding can confirm a clostridium perfringus myconecrosis | black thin exudate
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| how do you treat myconecrosis | abx, hyparbaric Ox, amputation
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| how does clostridium perfringus avoid the immune system | perfringolysis kills PMNs
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| what toxin is necrotic and hemolytic | alpha toxin phospholipase c
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| what is another name for perfringolysin | Omega toxin
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| what toxin alters cell wall of the intestine | enterotoxin
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| what can cause endometritis or septicotoxemia after a mechanical abortion | c. perfringus
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| what causes pseudomembranous enterocolitis | C. difficile following abx
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| what exotoxins are involved in Pseudomembranous enterocolitis | Toxin A - diarrhea and Toxin B cytolytic
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| what do you see on colonoscopy | red inflamed mucosa and white exudates
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| how do you treat C. difficile | take Metronidazole or a Vancomyosin down to the GI tract
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| Food poisoning is via | Type A enterotoxin
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| how long does food poisoning via C. difficile take to show up | 8-24 hours
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| wha does toxin C do with C. perfringus food poisoning | Beta toxin that causes necrotizing enteritis-jejunum (pig-bel)
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| can c. perfringus tolerate aerobic conditions | yes but it is an anerobe
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| how does C. perfringus cause food poisoning | by altering glucose transport
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| how could you tell c. perfringus from s. aureus | s. aureus more emetic C. perfringus is diarrhea and takes 8 hours not .5 like aureus
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| when would you get endometriosis or septicotoxemia | uterine myonecrosis following a mechanical abortion
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| why is there a vaccine for tetanus but not botulism | tetanus has one serotype and botulism has 7
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