click below
click below
Normal Size Small Size show me how
BACT: C Perf.
DD
Question | Answer |
---|---|
O2 requirement of Clost | anaerobic (canned food) |
Fn of clostridium botulism | blocks ACh release (floppy) |
how do you treat botulism | antitoxin, intubation, hyparbaric O2 |
how does infantile botulism present | constipation 2-3 days then trouble swollowing |
C. tetani has what exotoxin | tetanospasmin |
mechanism of tetanus | prevents GABA and Glycine release |
two characteristic findings of tetanus | Trismus, and Ridus sardonicus |
how do you treat tetanus | neutralize, immunization boster, clean wound, abx, supportive care |
C. perfringus is normally found? | GI and vagina |
how common are leukocytes with gas gangrene | none |
what types of C. perfringus causes gangreen | types A-E |
where does C. perfringus grow with cellulitis | in necrotic tissue |
how can you tell it is cullulitis of c. perfringus | crackling texture |
how does clostridium mycronecrosis happen | trauma from spore innoculation into the muscle |
what will you see on ct of c. perfringus infection of the muscle | gas pockets |
what gross finding can confirm a clostridium perfringus myconecrosis | black thin exudate |
how do you treat myconecrosis | abx, hyparbaric Ox, amputation |
how does clostridium perfringus avoid the immune system | perfringolysis kills PMNs |
what toxin is necrotic and hemolytic | alpha toxin phospholipase c |
what is another name for perfringolysin | Omega toxin |
what toxin alters cell wall of the intestine | enterotoxin |
what can cause endometritis or septicotoxemia after a mechanical abortion | c. perfringus |
what causes pseudomembranous enterocolitis | C. difficile following abx |
what exotoxins are involved in Pseudomembranous enterocolitis | Toxin A - diarrhea and Toxin B cytolytic |
what do you see on colonoscopy | red inflamed mucosa and white exudates |
how do you treat C. difficile | take Metronidazole or a Vancomyosin down to the GI tract |
Food poisoning is via | Type A enterotoxin |
how long does food poisoning via C. difficile take to show up | 8-24 hours |
wha does toxin C do with C. perfringus food poisoning | Beta toxin that causes necrotizing enteritis-jejunum (pig-bel) |
can c. perfringus tolerate aerobic conditions | yes but it is an anerobe |
how does C. perfringus cause food poisoning | by altering glucose transport |
how could you tell c. perfringus from s. aureus | s. aureus more emetic C. perfringus is diarrhea and takes 8 hours not .5 like aureus |
when would you get endometriosis or septicotoxemia | uterine myonecrosis following a mechanical abortion |
why is there a vaccine for tetanus but not botulism | tetanus has one serotype and botulism has 7 |