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BACT: C Perf.
DD
| Question | Answer |
|---|---|
| O2 requirement of Clost | anaerobic (canned food) |
| Fn of clostridium botulism | blocks ACh release (floppy) |
| how do you treat botulism | antitoxin, intubation, hyparbaric O2 |
| how does infantile botulism present | constipation 2-3 days then trouble swollowing |
| C. tetani has what exotoxin | tetanospasmin |
| mechanism of tetanus | prevents GABA and Glycine release |
| two characteristic findings of tetanus | Trismus, and Ridus sardonicus |
| how do you treat tetanus | neutralize, immunization boster, clean wound, abx, supportive care |
| C. perfringus is normally found? | GI and vagina |
| how common are leukocytes with gas gangrene | none |
| what types of C. perfringus causes gangreen | types A-E |
| where does C. perfringus grow with cellulitis | in necrotic tissue |
| how can you tell it is cullulitis of c. perfringus | crackling texture |
| how does clostridium mycronecrosis happen | trauma from spore innoculation into the muscle |
| what will you see on ct of c. perfringus infection of the muscle | gas pockets |
| what gross finding can confirm a clostridium perfringus myconecrosis | black thin exudate |
| how do you treat myconecrosis | abx, hyparbaric Ox, amputation |
| how does clostridium perfringus avoid the immune system | perfringolysis kills PMNs |
| what toxin is necrotic and hemolytic | alpha toxin phospholipase c |
| what is another name for perfringolysin | Omega toxin |
| what toxin alters cell wall of the intestine | enterotoxin |
| what can cause endometritis or septicotoxemia after a mechanical abortion | c. perfringus |
| what causes pseudomembranous enterocolitis | C. difficile following abx |
| what exotoxins are involved in Pseudomembranous enterocolitis | Toxin A - diarrhea and Toxin B cytolytic |
| what do you see on colonoscopy | red inflamed mucosa and white exudates |
| how do you treat C. difficile | take Metronidazole or a Vancomyosin down to the GI tract |
| Food poisoning is via | Type A enterotoxin |
| how long does food poisoning via C. difficile take to show up | 8-24 hours |
| wha does toxin C do with C. perfringus food poisoning | Beta toxin that causes necrotizing enteritis-jejunum (pig-bel) |
| can c. perfringus tolerate aerobic conditions | yes but it is an anerobe |
| how does C. perfringus cause food poisoning | by altering glucose transport |
| how could you tell c. perfringus from s. aureus | s. aureus more emetic C. perfringus is diarrhea and takes 8 hours not .5 like aureus |
| when would you get endometriosis or septicotoxemia | uterine myonecrosis following a mechanical abortion |
| why is there a vaccine for tetanus but not botulism | tetanus has one serotype and botulism has 7 |
Created by:
jmuame03
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