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Pharmacy Practice III - Medications 001-050

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Question
Answer
Coumadin: class & indications?   Vitamin K antagonist, venous thromboembolism prophylaxis treatment, atrial fibrillations, heart valves  
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Urecholine: indications?   Urinary retention  
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Bethanechol: class & dosage?   Cholinergic, tablets  
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Urecholine (Bethanechol): comments?   Bladder smooth muscle, useful post-op/post-partum, 30-60 mins ac -> systemic absorp -> dec. N/V  
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Isopto Carpine: indications?   Open angle glaucoma  
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Pilocarpine: class & dosage?   Cholinergic, eye drops  
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Isopto Carpine (pilocarpine): comments?   Miotic, decrease intraocular pressure  
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Aricept: indication?   Mild/moderate Alheimer's  
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Donepezil: class & dosage?   Cholinergic, 5mg q hs  
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Aricept (donepezil): comments?   Reversible AChE inhibitor, AE: N/A/D, wt loss, Take at night to (x) AE  
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Warfarin sodium: dosage?   2-10mg daily  
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Coumadin (warfarin sodium): comments?   Narrow therapeutic index, dosage regimens vary widely, dosage tab strengths (1,2,2.5,3,4,5,6,7.5,10), increases drug interaction, adverse effects of bleeding/bruising, pt education, use as directed, avoid alcohol & aspirin, inr target 2-3  
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Reserpine: class & indication?   B antagonist, hypertension  
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Reserpine: dosage?   Tablet  
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Reserpine (reserpine): comments?   CV agent: depletes stores of catecholamines & 5-HT, increased AE of depression  
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Isopto Atropine: indication?   To cause mydrisas/cycloplegia  
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Atropine: class & dosage?   Anti-cholinergic, eye drops  
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Isopto Atropine (atropine): comments?   Relax sphincter MM in iris/ciliary body, Photophobia, Tx: cardiac arrest (inc. HR)  
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Transderm-Scop: indication?   Nausea/vomiting, motion sickness  
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Scopolamine: class & dosage?   Anti-cholinergic, topical patch  
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Transderm-Scop (scopolamine): comments?   AE: drowsiness, Apply behind ear 4h prior, Replace q 72h  
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Cogentin: indication?   Parkinson's  
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Benztropine: class & dosage?   Anti-cholinergic, 0.5 - 2mg daily  
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Cogentin (benztropine): comments?   Caution hot weather, decreases cholngrc tone due to dopamine deficiency  
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Bentyl: indication?   IBS  
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Dicyclomine: class & dosage?   Anti-cholinergic, 20-40mg tid-qid  
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Bentyl (dicyclomine): comments?   Relax GI smMM, Take 30 min ac for sys. absorp Inc. [] when Sx begin  
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Levsin: indication?   IBS  
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Hyoscyamine 0.125mg: class & dosage?   Anti-cholinergic, 0.125-0.25mg q 4h prn  
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Levsin (hyoscyamine): comments?   Relax GI smMM, Oral: 30 min ac, SL: faster peak  
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Levsinex/Levbid: indication?   IBS  
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Hyoscyamine 0.375mg: dosage?   1-2 q 12h  
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Levsinex/Levbid (hyoscyamine): comments?   Relax GI smMM, take on schedule, NOT prn dosing  
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Ditropan/XL: indication?   Overactive bladder  
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Oxybutynin: class & dosage?   Anti-cholinergic, 5mg tid, 5mg XL qd  
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Ditropan/XL (oxybutynin): comments?   Relax bladder smMM, AE: xerostomia, drowsiness, constipation  
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Detrol/LA: indication?   Overactive bladder  
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Tolterodine: class & dosage?   Anti-cholinergic, 2mg tab bid, 4mg LA cap qd  
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Coreg: class & indication?   B Antagonist, CHF & HTN  
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Carvedilol: dosage?   Starting dose of 3.125 mg bid, under 85kg 25mg bid, over 85kg 50mg bid for CHF, HTN 25mg bid  
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Coreg (carvedilol): comments?   Also a nonselective a1 antagonist, take w/ food to decrease cmax to decrease a1 activities to decrease dizziness, counsel that it will feel worse before better  
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Normodyne, Trandate: class & indication?   B Antagonist nonselective, HTN  
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Labetalol: dosage?   200mg bid  
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Normodyne, Trandate (labetalol): comments?   Also a1 antagonist, increase dizziness  
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Cosopt: class & indication?   B antagonist, open-angle glaucoma  
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Dorzolamide, timolol: dosage?   1 gtt in affected eye(s) bid  
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Cosopt (dorzolamide, timolol): comments?   Carbonic anhydrase inhibition or decrease formation of aqueous humor, PDR: drug-disease interaction, asthma  
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Timoptic: class & indication?   B antagonist non-selective, open-angle glaucoma  
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Timolol: dosage?   1 gtt in affected eye(s) bid  
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Timoptic (timolol): comments?   PDR: drug-disease interaction, asthma  
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Tenormin: class & indication?   B1 antagonist, angina pectoris (long term), HTN  
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Atenolol: dosage?   50-200 mg qd angina pectoris, 50-100mg qd htn  
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Tenormin (atenolol): comments?   Adherence important: upregulation can cause rebound HTN  
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Zebeta: class & indication?   B1 antagonist, HTN  
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Bisoprolol: dosage?   2.5-10mg qd  
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Zebeta (bisoprolol): comments?   adherence important: upregulation can cause rebound HTN  
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Beoptic: class & indication?   B1 antagonist, open-angle glaucoma  
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Betaxolol: dosage?   1-2 gtts in affected eye(s) bid  
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Beoptic (betaxolol): comments?   decrease formation of aqueous humor  
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Inderal LA: class & indication?   B1 & B2 antagonist, HTN, angina prophylaxis  
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Propranolol: dosage?   30-160mg qd angina prophylaxis, 120-160mg qd HTN  
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Inderal LA (propranolol): comments?   PDR: drug-disease interaction, asthma, adherence important: upregulation can cause rebound HTN  
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Toprol XL: class & indication?   B1 antagonist, HTN, CHF, angina pectoris (long term)  
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Metoprolol succinate: dosage?   12.5-25mg qd CHF, 25-100mg qd HTN, 100mg qd angina pectoris (long term)  
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Toprol XL (metoprolol succinate): comments?   up to 400mg qd, for angina pectoris & HTN, up to 200mg qd for CHF, do not give if acutely symptomatic; stable give low dose to inhibit reflex overdrive then titrate overtime to live longer (CHF?)  
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Atrovent: indication?   Asthma maintenance  
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Iprotropium: class & dosage?   Anti-cholinergic 2 puffs (or 1 vial neb) tid-qid  
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Atrovent(iprotropium): comments?   NOT rapid acting, use on schedule DoA: 4-6h  
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Combivent: indication?   Asthma maintenance  
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Iprotropium/albuterol(not Duoneb): class & dosage?   Anti-cholinergic 2 puffs qid  
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Combivent(ipratropium/albuterol): comments?   Use on schedule PDR: days supply, over/underutilization  
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Duoneb: indication?   Asthma maintenance  
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Ipratropium/albuterol(not Combivent): class & dosage?   Anti-cholinergic Nebulizer 1 vial qid  
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Duoneb(iprotropium/albuterol): comments?   Use on schedule PDR: days supply, over/underutilization  
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Lopressor: class & indication?   B1 antagonist, HTN, acute MI  
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Metoprolol tartrate: dosage?   100 mg qd or 50mg bid  
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Lopressor (metoprolol tartrate): comments?   take w/ food to increase absorption, adherence important: upregulation can cause rebound HTN  
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Flomax: class & indication?   selective a1 antagonist, BPH  
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Tamsulosin: dosage?   0.4 to 0.8mg qd  
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Flomax (tamsulosin): comments?   Administer 30 min. before meal to decrease Cmax, delay Tmax, decrease AUC to decrease hypotensive effects, adherence important: sensitization can cause exaggerated hypotensive affect upon readministration  
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Proventil aerosol MDI: class & indication?   B2 agonist, asthma rescue, bronchodilator  
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Albuterol MDI: dosage?   1-2 puffs q4-6 prn  
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Proventil (albuterol) MDI & inhalation solution: comments?   relax bronchial/uterine/vascular smooth muscle, can use 15 minutes prior to activity to prevent exercise induced bronchial spasms, AE: insomnia, nervousness, PDR: overutilization  
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Proventil inhalation solution: class & indication?   B2 agonist, asthma rescue, bronchodilator  
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Albuterol inhalation solution: dosage?   2.5mg tid-qid prn  
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Serevent Diskus: class & indication?   B2 agonist, asthma maintenance, bronchodilator  
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Spiriva: indication?   Asthma maintenance  
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Tiotropium: class & dosage?   Anti-cholinergic one 18mcg cap qd  
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Spiriva(tiotropium): comments?   t1/2: 5-6d Admin errors: repeat inhalation No systemic absorp if swallowed (+ charge+  
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Dopamine: indication?   Hemodynamic imbalances  
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Dopamine (generic): class & dosage?   Anti-cholinergic Injection  
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Dopamine(dopamine): comments?   Inc. renal BF/SBP/HR Short t1/2 -> IV Dose/kg/min -> rate/h  
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Sinemet: indication?   Parkinson's  
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Carbidopa/levodopa: class & dosage?   Anti-cholinergic Individualized Start 25/100mg tid  
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Sinemet(carbidopa/levodopa): comments?   10/100mg, 25/100mg, 25/250mg tabs L-dopa can X BBB -> dapamine in CNS Inc. dopamine in periphery -> nausea  
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Sinemet CR: indication?   Parkinson's  
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Carbidopa/levodopa(extended release): class & dosage?   Anti-cholinergic Individualized Start 50/200mg bid  
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Sinemet CR(carbidope/levodopa): comments?   25/100mg, 50/200mg tabs Scored, but do NOT crush/chew F: 70-75% vs. Sinemet  
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Dobutrex: indication?   Cardiac decompensation CHF  
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Dobutamine: class & dosage?   Anti-cholinergic Injection  
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Dobutrex(dobutamine): comments?   + inotrope Short t1/2 -> IV  
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Naphcon (eye)Privine (nasal): indication?   Ocular redness Nasal congestion  
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Naphazoline: class & dosage?   A-agonist Eyedrops Nasal spray  
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Naphcon/Privine(naphazoline): comments?   Imidazole Use < 3 days (rebound congestion)  
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OcuClear (eye)Afrin (nasal): indication?   Ocular redness Nasal congestion  
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Oxymetazoline: class & dosage?   A-agonist Eyedrops Nasal spray  
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OcuClear/Afrin(oxymetazoline): comments?   Imidazole Use < 3 days (rebound congestion)  
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Sudafed: indication?   Nasal congestion  
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Pseudoephedrine: class & dosage?   A-agonist 60mg q 4-6h prn (adults)  
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Sudafed(pseudoephedrine): comments?   Max dose: 240mg/day Inc. NE release -> indirect A-agonist Purchase limits: 3.6g/day; 9g/month  
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Salmeterol: dosage?   1 inhalation q12h  
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Serevent Diskus (salmeterol): comments?   long acting duration of action 12 hours, administer diskus technique, powder  
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Foradil Aerolizer: class & indication?   B2 agonist, asthma maintenance, bronchodilator  
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Formoterol: dosage?   one 12 mcg capsule inhaled q12h  
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Foradil Aerolizer (formoterol): comments?   can use 15 minutes prior to activity to prevent exercise induced bronchial spasms, long acting duration of action 12 hours, adminster inhalation device technique, capsule, keep upright  
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Maxair Autohaler: class & indication?   B2 agonist, asthma rescue, bronchodilator  
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Pirbuterol: dosage?   1-2 inhalations q4-6h prn  
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Maxair Autohaler (pirbuterol): comments?   can use 15 minutes prior to activity to prevent exercise induced bronchial spasms, administer autohaler technique, breath-activated, prime, shake, good for people w/ coordination difficulties  
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Xopenex inhalation solution: class & indication?   B2 agonist, asthma rescue, bronchodilator  
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Levalbuterol: dosage?   1 vial nebulized tid (dosage based on age)  
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Xopenex inhalation solution (levalbuterol): comments?   3 strengths solution (0.31, 0.63, 1.25mg/3mL), concentrate (1.25mg/0.5mL), must dilute concentrate, single isomer formulation of (R)-albuterol, if open must use in 2 weeks, if in light must use in 1 week, can use 15 min prior to activity to prevent EIBS  
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Brethine: class & indication?   B2 agonist, asthma rescue, bronchodilator  
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Terbutaline: dosage?   5mg tab tid, subq/oral  
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Brethine (terbutaline): comments?   off label "Tocolytic" agent to relax uterine smooth muscles associated w/ preterm labor  
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Sudafed PE (oral)Neo-Synephrine (nasal): indication?   Nasal congestion  
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Phenylephrine: class & dosage?   A-agonist Tab Nasal spray  
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Sudafed PE/Neo-Synephrine(phenylephrine): comments?   Topical use < 3 days (rebound congestion) Inc. est incident  
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Epinephrine: indication?   Respiratory distress Anaphylaxis  
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Epinephrine: class & dosage?   A-agonist Injection  
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Epinephrine(epinephrine): comments?   A & B agonist Type 1 hypers. Rxns: vasocons, bronchodil. Epipen & Epipen JR  
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Catapres: indication?   HTN  
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Clonidine: class & dosage?   A2-agonist 0.1-0.4mg bid  
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Catapres(clonidine): comments?   Start with 0.1mg bid Compliance essential -> rebound HTN A2-agonists: (x) CNS symp. outflow  
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Catapres-TTS: indication?   HTN  
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Clonidine (patches): class & dosage?   A2-agonist 0.1mg patch q 7d  
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Catapres-TTS(clonidine): comments?   Rotate site once/week Compliance essential -> rebound HTN A2-agonist: (x) CNS symp. outflow  
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Alphagan P: indication?   Open angle glaucoma  
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Brimonidine: class & dosage?   A2-agonist 1 gtt q8h  
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Alpahgan P(brimonidine): comments?   Dec. aq. humor production, inc. outflow Wait 5 mins before other eyedrops  
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Alupent: class & indication?   B2 agonist, asthma rescue, bronchodilator  
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Metaproterenol: dosage?   oral inhalation  
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Alupent (metaproterenol): comments?   not used much, no advantage over Xopenex  
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Amitriptyline: class & indication?   Tricyclic, depression  
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Amitriptyline: dosage?   40-150mg in divided doses or qhs  
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Amitriptyline (amtriptyline): comments?   NT reuptake inhibitation which potentials NE & 5-HT, off label for neuropathic pain  
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Tofranil: class & indication?   Tricyclic, childhood enuresis (>6 y/o)  
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Imipramine: dosage?   50-75mg qhs childhood enuresis, 50-150mg qd depression, 2.5mg/kg/day NMT or determine pediatric weight bc EKG/arrhythmia abnormalities can cause cardiotoxicity  
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Tofranil (imipramine): comments?   NT reuptake inhibitor  
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Tofranil, Tofranil PM caps: class & indication?   Tricyclic, depression  
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Minipress: indication?   HTN  
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Prazosin: class & dosage?   A1-antagonist 2-5mg tid  
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Minipress(prazosin): comments?   1st dose HTN: take at hs Adherence important: sensitization, exaggerated hypotensive affect upon readmin.  
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Cardura: indication?   HTN BPH  
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Doxazosin: class & dosage?   A1-antagonist 1-16mg qd  
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Cardura(doxazosin): comments?   1st dose HTN: take at hs Adherence important: sensitization, exaggerated hypotensive affect upon readmin.  
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Cardura XL: indication?   BPH  
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Doxazosin(extended release): class & dosage?   A1-antagonist 4mg qd  
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Cardura XL(doxazosin): comments?   Can be admin. AM. 1st dose HTN  
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Hytrin: indication?   HTN BPH  
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Terazosin: class & dosage?   A1-antagonist 1-5mg qd  
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Hytrin(terazosin): comments?   1st dose HTN Niche: add-line agen Sensitization upon readmin.  
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Pamelor: class & indication?   Tricyclic, depression  
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Nortriptyline: dosage?   75-150mg qd  
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Pamelor (nortriptyline): comments?   less drowsiness than other tricyclic, NT reuptake inhibitor  
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Nardil: class & indication?   nonselective MAO, depression  
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Phenelzine: dosage?   tab  
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Nardil (phenelzine): comments?   Food interaction w/ tyramine (cheese, meat, alcohol), increases drug interactions  
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