Acute Inflammation
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Acute Inflammation is characterized by: | Edema and Neutrophils
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2 Stimuli for acute inflammation | Infection and Tissue Necrosis
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Factors of Acute Inflammation | TLR
Arachidonic Acids
Mast cells
Complement
Hageman Factor
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CD14 is a TLR that recognizes which PAMP? | LPS, which is on all gram neg. bacteria
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TLR activates up-regulation of ___ | NF-KB
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2 enzymes that act on Arachidonic Acid | Cyclooxygenase and 5-lipooxygenase
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What are the products of Cyclooxygenase and its functions? | Prostaglandins
PGI2, PGD2, PGE2 = vasodilation and increase vascular permeability
PGE2 = fever and pain
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What are the products of 5-lipooxygenase and its functions? | Leukotrienes
LTB4 = attract and activate Neutrophils
LTC4, LTD4, LTE4 = vasoconstriction, bronchospasm, increase vascular permeability
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3 factors that activate Mast Cells are? | Tisse trauma
Complements (C3a + C5a)
IgE binding to antigen
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What are Hageman Factors? | Inactive proinflammatory proteins that are produced in the liver. Activated when they are exposed to tissue collagen
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What is a possible consequence of activated Hageman Factor? | DIC from coagulation and fibrinolytic system
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What are the cardinal signs of acute inflammation? | Rubor, Calor, Tumor, Dolor, Fever
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What causes fever in the inflammation? | Macrophage releases IL1 and TNF -> COX activity is increased -> More PGE2 is released -> Fever
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Created by:
soobyung92
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