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Acute Inflammation

Acute Inflammation is characterized by: Edema and Neutrophils
2 Stimuli for acute inflammation Infection and Tissue Necrosis
Factors of Acute Inflammation TLR Arachidonic Acids Mast cells Complement Hageman Factor
CD14 is a TLR that recognizes which PAMP? LPS, which is on all gram neg. bacteria
TLR activates up-regulation of ___ NF-KB
2 enzymes that act on Arachidonic Acid Cyclooxygenase and 5-lipooxygenase
What are the products of Cyclooxygenase and its functions? Prostaglandins PGI2, PGD2, PGE2 = vasodilation and increase vascular permeability PGE2 = fever and pain
What are the products of 5-lipooxygenase and its functions? Leukotrienes LTB4 = attract and activate Neutrophils LTC4, LTD4, LTE4 = vasoconstriction, bronchospasm, increase vascular permeability
3 factors that activate Mast Cells are? Tisse trauma Complements (C3a + C5a) IgE binding to antigen
What are Hageman Factors? Inactive proinflammatory proteins that are produced in the liver. Activated when they are exposed to tissue collagen
What is a possible consequence of activated Hageman Factor? DIC from coagulation and fibrinolytic system
What are the cardinal signs of acute inflammation? Rubor, Calor, Tumor, Dolor, Fever
What causes fever in the inflammation? Macrophage releases IL1 and TNF -> COX activity is increased -> More PGE2 is released -> Fever
Created by: soobyung92