Kidney 1 - Guyton
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| What is the kidneys function? | 1)excretion of metabolic waste products and foreigen chemicals 2)regulation of water,electrolyte,osmolality, electrolyte concentration 3)reg. acid-base balance 4)reg. arterial pressure 5)hormone sec. 6)gluconeogenesis
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| What kind of waste products? | Urea, creatine, uric acid, bilirubin, metabolic wastes, things not needed by body and toxins.
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| Describe the renal blood supply. | Renal arterie->
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| What is a nephron? | Kidneys functional unit includes glomerule, bowmanscapsel and tubule
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| Descibe the different between cortical and juxtamedullary nephorns! | Cortical<-cortex, Juxtamedullary<-medulla - vasa recta (supplies medulla with nutrition)- concentrates the urine
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| Urinary formation is a result of? | Glomerule filtration, tubular reabsorbtion and tubuar secretion.
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| Why is secretion important? | It determents the amount of K and H excreted in urine.
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| Why does our body filtrate a large amount of fluid and then reabsors it? | 1) to be able to remove wastes fast 2)high GFR allow all fluid to be filtred and processed many time per day (60X)
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| What does the filtrated fluid contain? | Its has the same organic and solute concentration as plasma but absent of protien.
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| What is not filtered? | Ca and fatty acids and large particles.
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| How many precent of renal plasma is filtered? | 20%
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| What is the filtration fraction? | Ff=Gfr/renal plasma flow (0,2=120/600)
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| What does increased Ff lead to? | (blank)
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| What happens when glomerular cap hydrostatic pressure changes? | increased HP->Inc. GFR | decreased HP->decreased GFR
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| What is glomerular hydrostatic pressure determined by? | 1)Arterial pressure 2)aff. arteriol resistens 3) efferent arteriol resistens
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| What happens when you change things that determins hydrostatic pressure? | incr. arteriol pressure->incr. GFR | incr. affer resistens->decr. GFR | incr. efferent resistens->incr.GFR (But to much->decr. GFR)
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| Describe the filtration barrier! | 1) endothelial, fenestrated 2)basmentmembrane 3)podocytes
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| Explain why negatibly charged molecules have difficulty passing the filtration barrier! | Because of the negative charge barrier in basment and podocytes.
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| What determents GFR? | GFR=Kf X (Pg-Pb-Cg+Cb) (125=12,5x(60-18-32+10))
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| Increased bowman's capsule hydrostatic pressure leads to? | Stones->increased pressure-->decreased GFR->damages kidney
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| Increased glomerular capillary colloid osmotic pressure leads to? | Decreased GFR, (without this force all plasma would be filtrated)
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| Why does the glomerular capillary colloid osmotic preussure rise from afferent to efferent arteriol? | Because of filtration which leads to incr. glomerular colloid osmotic pressure (more protiens then before)
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