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Kidney 1 - Guyton

What is the kidneys function? 1)excretion of metabolic waste products and foreigen chemicals 2)regulation of water,electrolyte,osmolality, electrolyte concentration 3)reg. acid-base balance 4)reg. arterial pressure 5)hormone sec. 6)gluconeogenesis
What kind of waste products? Urea, creatine, uric acid, bilirubin, metabolic wastes, things not needed by body and toxins.
Describe the renal blood supply. Renal arterie->
What is a nephron? Kidneys functional unit includes glomerule, bowmanscapsel and tubule
Descibe the different between cortical and juxtamedullary nephorns! Cortical<-cortex, Juxtamedullary<-medulla - vasa recta (supplies medulla with nutrition)- concentrates the urine
Urinary formation is a result of? Glomerule filtration, tubular reabsorbtion and tubuar secretion.
Why is secretion important? It determents the amount of K and H excreted in urine.
Why does our body filtrate a large amount of fluid and then reabsors it? 1) to be able to remove wastes fast 2)high GFR allow all fluid to be filtred and processed many time per day (60X)
What does the filtrated fluid contain? Its has the same organic and solute concentration as plasma but absent of protien.
What is not filtered? Ca and fatty acids and large particles.
How many precent of renal plasma is filtered? 20%
What is the filtration fraction? Ff=Gfr/renal plasma flow (0,2=120/600)
What does increased Ff lead to? (blank)
What happens when glomerular cap hydrostatic pressure changes? increased HP->Inc. GFR | decreased HP->decreased GFR
What is glomerular hydrostatic pressure determined by? 1)Arterial pressure 2)aff. arteriol resistens 3) efferent arteriol resistens
What happens when you change things that determins hydrostatic pressure? incr. arteriol pressure->incr. GFR | incr. affer resistens->decr. GFR | incr. efferent resistens->incr.GFR (But to much->decr. GFR)
Describe the filtration barrier! 1) endothelial, fenestrated 2)basmentmembrane 3)podocytes
Explain why negatibly charged molecules have difficulty passing the filtration barrier! Because of the negative charge barrier in basment and podocytes.
What determents GFR? GFR=Kf X (Pg-Pb-Cg+Cb) (125=12,5x(60-18-32+10))
Increased bowman's capsule hydrostatic pressure leads to? Stones->increased pressure-->decreased GFR->damages kidney
Increased glomerular capillary colloid osmotic pressure leads to? Decreased GFR, (without this force all plasma would be filtrated)
Why does the glomerular capillary colloid osmotic preussure rise from afferent to efferent arteriol? Because of filtration which leads to incr. glomerular colloid osmotic pressure (more protiens then before)
Created by: Malekian