Cytokines in Immunology Matching
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each of the black spaces below before clicking
on it to display the answer.
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| IL-2 | Th1 cells | Th1: increase IL-2 high affinity receptors, increase IL-2 production, upregulate adaptive immune system
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| IL-3 | Activated T helper cells | Hematopoietic stem cell differentiation
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| IL-4 | Th2 cells, Treg cells | B cell differentiation + class switch to IgE
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| IL-5 | Th2 cells | B cell differentiation + class switch to IgA
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| IL-6 | Th2 cells, APCs | B cell conversion to plasma cells; plasma cell secretion of antibody; hepatocyte secretion of acute phase reactants
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| IL-8 (CXCL8) | Macrophages | Neutrophil chemotaxis
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| IL-10 | Th2 + Treg cells | Activates Th2, Inhibits Th1
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| IL-12 | APCs | Induces CD4+ cell differentiation into Th1 cells; activates Th1 cells; activates NK cells
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| IL-13 | Th2, Mast cells, NK cells | Activate macrophages; stimulate IgE production
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| IFN-gamma | Th1 cells, NK cells | Activate macrophages, B cells, NK cells; Inhibit Th2 cells; suppress viral replication
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| TNF-alpha | APCs, Th1 cells | Increases IL-2 receptor synthesis in TH1 cells; increases B cell proliferation; neutrophil chemotaxis; systemic + local inflammatory mediator
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| GM-CSF | Th1 + Th2 cells | Leukocyte differentiation from myeloid progenitor cells
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| IL-1 | APCs | Inflammatory + Pyrogenic
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