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Cytokine Matching

Cytokines in Immunology Matching

CytokineSourceMain target + effect
IL-2 Th1 cells Th1: increase IL-2 high affinity receptors, increase IL-2 production, upregulate adaptive immune system
IL-3 Activated T helper cells Hematopoietic stem cell differentiation
IL-4 Th2 cells, Treg cells B cell differentiation + class switch to IgE
IL-5 Th2 cells B cell differentiation + class switch to IgA
IL-6 Th2 cells, APCs B cell conversion to plasma cells; plasma cell secretion of antibody; hepatocyte secretion of acute phase reactants
IL-8 (CXCL8) Macrophages Neutrophil chemotaxis
IL-10 Th2 + Treg cells Activates Th2, Inhibits Th1
IL-12 APCs Induces CD4+ cell differentiation into Th1 cells; activates Th1 cells; activates NK cells
IL-13 Th2, Mast cells, NK cells Activate macrophages; stimulate IgE production
IFN-gamma Th1 cells, NK cells Activate macrophages, B cells, NK cells; Inhibit Th2 cells; suppress viral replication
TNF-alpha APCs, Th1 cells Increases IL-2 receptor synthesis in TH1 cells; increases B cell proliferation; neutrophil chemotaxis; systemic + local inflammatory mediator
GM-CSF Th1 + Th2 cells Leukocyte differentiation from myeloid progenitor cells
IL-1 APCs Inflammatory + Pyrogenic
Created by: eemolee27