Fevers facts WCMC Lecture
Quiz yourself by thinking what should be in
each of the black spaces below before clicking
on it to display the answer.
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| What is the febrile response? | Physiologic rxn to disease involving 1) cytokine response 2) Acute Phase Reactants 3) Activation of numerous systems - physiologic - Endocrine - Immunologic
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| Name some endogenous pyrogens | IL1, TNF, IL6, IFN gamma, gp 130, Ciliary Neutropic factors, IL 11
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| Name some exogenic pyogens | Microbial cell products, microbial toxins, drugs, pyogenic factors, complement, Antigen-antibody complexes
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| Mechanisms of thermal regulation? | Body heat production, loss of body heat, Blood ciculation
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| What is the difference between fever and hyperthermia? | 1) Fever is when set point is increased because of cytokines, 2)Hyperthermia is when set point fine but mechanism of thermoregulation is overwhelmed
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| What are some of the responses to fever? | Metabolic changes, Nutritional consequences, altered hepatocyte fxn
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| What are the benefits/harms of fever? | benefits - Antimicrobial, Immunologic defense
harms - Febrile convulsions, encephalitis, catabolism, delerium,
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| What kind of fever pattern does malaria show? | Intermittent/spiking, Quitodian Teritian
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| What kind of fever pattern is ratbite/lymphoma? | Relapsing/Periodic
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| Do you get rashes with fever? | Yes, Macules and papules, vesciles and bullae, Petechiae and purpura
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| Name the common etiologies of FUO? | Lymphoma/Leukemia, solid tumors, Biliary tract disease, TB, Endocarditis, Abdominal abscesses, No diagnosis
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