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Fevers Facts
Fevers facts WCMC Lecture
Question | Answer |
---|---|
What is the febrile response? | Physiologic rxn to disease involving 1) cytokine response 2) Acute Phase Reactants 3) Activation of numerous systems - physiologic - Endocrine - Immunologic |
Name some endogenous pyrogens | IL1, TNF, IL6, IFN gamma, gp 130, Ciliary Neutropic factors, IL 11 |
Name some exogenic pyogens | Microbial cell products, microbial toxins, drugs, pyogenic factors, complement, Antigen-antibody complexes |
Mechanisms of thermal regulation? | Body heat production, loss of body heat, Blood ciculation |
What is the difference between fever and hyperthermia? | 1) Fever is when set point is increased because of cytokines, 2)Hyperthermia is when set point fine but mechanism of thermoregulation is overwhelmed |
What are some of the responses to fever? | Metabolic changes, Nutritional consequences, altered hepatocyte fxn |
What are the benefits/harms of fever? | benefits - Antimicrobial, Immunologic defense harms - Febrile convulsions, encephalitis, catabolism, delerium, |
What kind of fever pattern does malaria show? | Intermittent/spiking, Quitodian Teritian |
What kind of fever pattern is ratbite/lymphoma? | Relapsing/Periodic |
Do you get rashes with fever? | Yes, Macules and papules, vesciles and bullae, Petechiae and purpura |
Name the common etiologies of FUO? | Lymphoma/Leukemia, solid tumors, Biliary tract disease, TB, Endocarditis, Abdominal abscesses, No diagnosis |