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Duke PA Inflammatory Bowel Disease

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Question
Answer
what are the two types of IBD   Crohn's, and ulcerative colitis  
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incidence of IBD is highest in   westernized countries  
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Crohn's disease is more common in   whites (traditionally Ashkenazi Jews have been at higher risk)  
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there is a low incidence of Crohn's disease in __ populations   Hispanics and Asian  
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common symptoms of IBD   diarrhea (often bloody), fatigue (anemia), weight loss, anorexia, N/V, crampy abdominal pain  
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can affect any portion of the GI tract (lips to anus), disease tends to skip areas, disease is transmural (involves the entire thickness of the wall)   Crohn's disease  
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limited to the colon, disease starts in the rectum (proctitis), disease is usually continuous, more superficial disease   Ulcerative colitis  
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proctitis often results in __   tenesmus  
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feeling of incomplete evacuation of the rectum   tenesmus  
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IBD tends to have a __ course   relapsing and remitting  
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IBD is an __ disorder not infectious   immune  
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IBD exact etiology   unknown, but the working hypothesis is that this is an abnormal immune response to bacteria within the gut  
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with ulcerative colitis b/c the rectum is almost universally involved, __ is more common   bloody diarrhea  
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CD is associated with __ both around the anus and internally   fistula  
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fistulas can lead to __   abscesses  
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CD is associated with __ of the intestine which can lead to blockages   stricture  
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__ + Crohn's = BAD   smoking  
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for UC.CD there is a strong association with __   primary biliary cirrhosis  
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primary biliary cirrhosis is often first recognized by __   alkaline phosphatase  
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primary manifestation of biliary cirrhosis is __. There is no effective therapy for this, refer to hepatologist   stricturing of the bile ducts  
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arthralgia associated with IBD flares   type 1-self limited, short lived, affecting 6 or fewer joints  
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arthralgia not associated with IBD flares   type 2-multiple joints, can be migratory, can be more chronic  
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raised tender red-purplish nodules parallels IBD activity and responds to IBD therapy   erythema nodosum  
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wide spectrum of necrotic inflammation. parallels IBD activity about half the time, may respond to therapy aimed at IBD, dermatology should be involved, do not biopsy   pyoderma gangrenosum  
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big concern, eye pain, blurred vision, photophobia, headaches associated with IBD. prompt diagnosis and treatment to prevent complications. Get Ophtho involved   Uveitis  
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IBD is most often diagnosed in the __   young  
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tenesmus is suggestive of __   proctitis  
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gold standard diagnostic for IBD   there is none. diagnosis relies on a combination of endoscopy, histology, radiography, laboratory, and clinical data  
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do not order __ if IBD is suspected   serologies  
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#1 risk factor for IBD   family history  
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Ulcerative colitis treatment   5-ASA, corticosteroids, 6-MP/azathioprine, Infliximab  
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Crohn's disease   5-ASA, Corticosteroids, 6-MP/azathioprine, methotrexate, infliximab, natalizumab  
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with IBD use as little __ as possible   steroids  
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mild ulcerative colitis   no more than 4 BM/d (with/without blood) no signs of systemic toxicity (i.e. fever, tachycardia, anemia), and normal ESR  
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severe ulcerative colitis   >6 BM/d and evidence of systemic toxicity.  
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goal of corticosteroids in IBD   is to use sparingly and for a limited time (to induce remission during a flare)  
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drug that impairs T cell function, Slow onset of action (3-6 months), often introduced with steroids and steroids are then weaned off, AE's-cytopenia, liver toxicity, pancreatitis   6-MP/Azathioprine  
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high risk for tuberculosis with __ for IBD. Must have a PPD before onset of medication   anti-TNF antibodies  
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__ may necessitate colectomy   dysplasia, cancer, or toxic colitis  
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__ may necessitate segmental resection in Crohn's   fibrotic strictures, obstruction, fistulae  
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generally try to avoid __ in Crohn's unless absolutely necessary   surgery  
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air in pee(pneumaturia) makes you think __   fistula to bladder  
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high fever/abdominal mass with IBD =   abscess, liver abscess  
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severe abdominal pain with IBD =   perforation  
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N/V with IBD =   obstruction  
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severe rectal pain with IBD =   perirectal abscess  
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frequent UTI's/pneumaturia with IBD =   fistula to bladder  
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in the case of flares with IBD steroids should work quickly, if things aren't improving __ may be warranted   endoscopy  
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