Pathology: Lectures 5 and 6 Renewal and Repair
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When does renewal occur | in cases where we loose our cells naturally (intestines lining, skin, etc..)
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When is regeneration of cells no longer able to occur | when parenchymal cells are lost
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What role do endothelial cells play in repair | they participlate in angiogenesis and thus facilitate bring blood flow back to the area
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What role do PMN's and macrophages play in repair | remove damage tissue and prevent infection
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What role to parenchymal cells play in repair | regenerate tissues with the primary functional cell type
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Are parencymal cells found in the heart? | NO
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What are charactestics of type I collagen | really strong and found in late wound healing
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Where would you find type IV collagen | in the basement membrane
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What are 2 traits of type III collagen | found in early wound healing and is fairly weak
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What happens in Hemostasis | fibrinogen is converted to fibrin
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What is a provisional matrix | this is an early/temporary cellular matrix that supports cellualr migration.
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Which collagen type is found in a provisional matrix | type 3
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Which cell types are found in granulation tissue | monocytes, plasma cells, and macrophages
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During re-epithelialization what is occuring | parenchymal cell recovery
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What structure/cell type is responsible for contraction | myofibroblast
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What day does contracture usually occur | day 3
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Which collagen type helps to regain tissue strength | type I
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Which type of tissue is vascular, resistent to infection, occurs between inflammation and contracture and secretes collagen? | granular tissue
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Which type of wound intention lends itself to fibrosis, less dense tissue and poor reapproxiamtion | secondary
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What are the three major influences on wound repair | Location, nature/amount of ECM, and Blood supply
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Will the kideny regenerate if there is minimal damage to the ECM | yes
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Which area of the kidney is most sussceptible to injur | medulla
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Which process occurs when there is chronic injury to the liver | fibrosis
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Do glomeruli regenerate | NO
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How do lung cells regenerate | Type 2 --> Type 1
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What does a patchy loss of cells in the heart signify | interstital fibrosis which could lead to cardiomyopathy or ishemic heart disease
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A difuse loss of cells in the heart signals what | myocardial infarction
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What type of necrosis follows and MI | coagulative
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Which type of nuerons have the ability to regenerate | PNS
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What type of cells do the scarring in the PNS | fibroblast
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Abnormal/pathologic contractures can cause bowel stricture if they occur where | abdomen
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A exuberant, disorganized deposition within the dermis that extends beyond the anatomic boundries of of normal sturcture is called what | Keloid
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Who is at risk for keloids | darker skined indivudals
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What is excessive scar formation referred to as | hypertrophic scars
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Which areas are prone to pathologic contractures | palms and shoes
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Are contractures common following burns | yes
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What is a pyogenic ganuloma | exuberant overgrowth of granulation tissue
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When are pyogenic granulomas likely to occur | on the gingiva of pregnant women
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granulation tissue that extends above the epithelial surface and precludes re-epithelialization is called what | proud flesh
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What is excessive, persistent fibrosis following an injury or surgical incision called | desmoids
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