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Pathology: Lectures 5 and 6 Renewal and Repair

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Question
Answer
When does renewal occur   in cases where we loose our cells naturally (intestines lining, skin, etc..)  
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When is regeneration of cells no longer able to occur   when parenchymal cells are lost  
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What role do endothelial cells play in repair   they participlate in angiogenesis and thus facilitate bring blood flow back to the area  
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What role do PMN's and macrophages play in repair   remove damage tissue and prevent infection  
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What role to parenchymal cells play in repair   regenerate tissues with the primary functional cell type  
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Are parencymal cells found in the heart?   NO  
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What are charactestics of type I collagen   really strong and found in late wound healing  
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Where would you find type IV collagen   in the basement membrane  
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What are 2 traits of type III collagen   found in early wound healing and is fairly weak  
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What happens in Hemostasis   fibrinogen is converted to fibrin  
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What is a provisional matrix   this is an early/temporary cellular matrix that supports cellualr migration.  
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Which collagen type is found in a provisional matrix   type 3  
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Which cell types are found in granulation tissue   monocytes, plasma cells, and macrophages  
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During re-epithelialization what is occuring   parenchymal cell recovery  
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What structure/cell type is responsible for contraction   myofibroblast  
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What day does contracture usually occur   day 3  
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Which collagen type helps to regain tissue strength   type I  
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Which type of tissue is vascular, resistent to infection, occurs between inflammation and contracture and secretes collagen?   granular tissue  
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Which type of wound intention lends itself to fibrosis, less dense tissue and poor reapproxiamtion   secondary  
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What are the three major influences on wound repair   Location, nature/amount of ECM, and Blood supply  
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Will the kideny regenerate if there is minimal damage to the ECM   yes  
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Which area of the kidney is most sussceptible to injur   medulla  
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Which process occurs when there is chronic injury to the liver   fibrosis  
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Do glomeruli regenerate   NO  
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How do lung cells regenerate   Type 2 --> Type 1  
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What does a patchy loss of cells in the heart signify   interstital fibrosis which could lead to cardiomyopathy or ishemic heart disease  
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A difuse loss of cells in the heart signals what   myocardial infarction  
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What type of necrosis follows and MI   coagulative  
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Which type of nuerons have the ability to regenerate   PNS  
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What type of cells do the scarring in the PNS   fibroblast  
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Abnormal/pathologic contractures can cause bowel stricture if they occur where   abdomen  
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A exuberant, disorganized deposition within the dermis that extends beyond the anatomic boundries of of normal sturcture is called what   Keloid  
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Who is at risk for keloids   darker skined indivudals  
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What is excessive scar formation referred to as   hypertrophic scars  
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Which areas are prone to pathologic contractures   palms and shoes  
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Are contractures common following burns   yes  
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What is a pyogenic ganuloma   exuberant overgrowth of granulation tissue  
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When are pyogenic granulomas likely to occur   on the gingiva of pregnant women  
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granulation tissue that extends above the epithelial surface and precludes re-epithelialization is called what   proud flesh  
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What is excessive, persistent fibrosis following an injury or surgical incision called   desmoids  
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