Basic Immunology Chapter 1
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| Immunology |
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| Immunity |
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| Innate Resistance |
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| Monocytes / Macrophages |
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| Granulocytes |
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| Neutrophils. |
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| Eosinophils |
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| Natural Killer Cells |
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| Chemotaxins |
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| Opsonin |
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| Defensins |
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| Oxidative Burst |
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| Probiotics |
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| Prebiotics |
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| Granulocytic Phagocytes |
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| Zymogens |
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| Differentiate First (barrier or external), second, and third (adaptive or acquired) lines of defense against infectious disease. |
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| Differentiate Inducible vs noninducible defense mechanisms |
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| Discuss characteristics of an immune response (specificity, memory, recognition) |
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| Discuss mechanisms involved in the first line of defense |
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| Discuss benefits vs disadvantages of iron supplements in terms of host defenses |
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| Discuss hygiene hypothesis and its role in immune response |
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| Discuss molecules involved in the attachment of PMNs to endothelial cells |
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| Discuss suspected relations between CRP and heart disease |
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| Discuss complement activation |
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| Discuss the effects of complement act INSERT |
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| Discuss the complement regulatory mechanisms |
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| Discuss clinical features that ELEVATE complement protein concentrations |
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| Discuss clinical features that DECREASE complement protein concentrations |
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| Compare four types of acquired immunity (eg active natural immunity) |
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| Compare roles physiologic factors have on host defense |
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| Compare classical, alternative, and lectin pathways of complement activation, including mode of activation, proteins involved, etc. |
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| Contrast cellular and humoral components of the innate immune responses |
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| Evaluate role of defensins in host protection against infectious diseases |
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| Evaluate the roles of macrophages and neutrophils in inflammation and phagocytosis |
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| Evaluate the complement system in protection again infectious diseases |
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| Describe the role of toll-like receptors in innate immunity |
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| Describe the role of normal microbiota in protection against infection |
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| Describe the sites and cells in the mononuclear phagocytic system |
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| Describe granulocytic phagocytes |
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| List examples of mononuclear cells |
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| Describe how phagocytes kill bacteria, including the role of the oxidaivete burst |
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| Arrange the events of phagocytosis in order from activation of cells to killing of bacteria |
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| List examples of opsonins |
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| Describe the key features of the inflammatory response |
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| List proteins that are referred to as acute phase reactants |
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| Explain the principle of the c-reactive protein (CRP) test and cite advantages over the erythrocyte sedimentation rate (ESR) as an indicator of inflammation |
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| Explain the use of CRP for monitoring the course of a disease |
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| Explain why the activation of complement INSERT STUFF |
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| Describe C3 convertase and C5 convertase in both the classical and alternative complement pathways. |
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| Identify the two major amplification steps in the classical complement cascade |
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| Identify the complement components in the membrane attack complex (MAC) |
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| Describe how the MAC causes lysis of target cells |
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