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Basic Immunology

Basic Immunology Chapter 1

Innate Resistance
Monocytes / Macrophages
Natural Killer Cells
Oxidative Burst
Granulocytic Phagocytes
Differentiate First (barrier or external), second, and third (adaptive or acquired) lines of defense against infectious disease.
Differentiate Inducible vs noninducible defense mechanisms
Discuss characteristics of an immune response (specificity, memory, recognition)
Discuss mechanisms involved in the first line of defense
Discuss benefits vs disadvantages of iron supplements in terms of host defenses
Discuss hygiene hypothesis and its role in immune response
Discuss molecules involved in the attachment of PMNs to endothelial cells
Discuss suspected relations between CRP and heart disease
Discuss complement activation
Discuss the effects of complement act INSERT
Discuss the complement regulatory mechanisms
Discuss clinical features that ELEVATE complement protein concentrations
Discuss clinical features that DECREASE complement protein concentrations
Compare four types of acquired immunity (eg active natural immunity)
Compare roles physiologic factors have on host defense
Compare classical, alternative, and lectin pathways of complement activation, including mode of activation, proteins involved, etc.
Contrast cellular and humoral components of the innate immune responses
Evaluate role of defensins in host protection against infectious diseases
Evaluate the roles of macrophages and neutrophils in inflammation and phagocytosis
Evaluate the complement system in protection again infectious diseases
Describe the role of toll-like receptors in innate immunity
Describe the role of normal microbiota in protection against infection
Describe the sites and cells in the mononuclear phagocytic system
Describe granulocytic phagocytes
List examples of mononuclear cells
Describe how phagocytes kill bacteria, including the role of the oxidaivete burst
Arrange the events of phagocytosis in order from activation of cells to killing of bacteria
List examples of opsonins
Describe the key features of the inflammatory response
List proteins that are referred to as acute phase reactants
Explain the principle of the c-reactive protein (CRP) test and cite advantages over the erythrocyte sedimentation rate (ESR) as an indicator of inflammation
Explain the use of CRP for monitoring the course of a disease
Explain why the activation of complement INSERT STUFF
Describe C3 convertase and C5 convertase in both the classical and alternative complement pathways.
Identify the two major amplification steps in the classical complement cascade
Identify the complement components in the membrane attack complex (MAC)
Describe how the MAC causes lysis of target cells
Created by: lovesintern



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