Duke PA Occupational/Interstitial/GranulomatousLung Disease
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| a virtual space between individual alveoli | interstitium
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| from inhalation of silica | silicosis
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| The chest film will reveal diffuse rounded opacities, Contraction of the lungs may occur, Upper lung zones are primarily affected | coal miner's lung
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| black lung | coal miner's lung
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| occupational lung disease caused by the inhalation of dust | pneumoconiosis
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| Most commonly associated with mining, insulation, shipbuilding, cement mixing and sandblasting related occupations | silicosis
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| Higher rate of pulmonary tuberculosis in ____ patients | silicosis
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| Hilar lymph nodes calcify forming “eggshell” calcifications on chest films | silicosis
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| may lead to pleural disease characterized by plaques, effusion and fibrosis | asbestosis
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| Mesothelioma, Bronchogenic Carcinoma are malignancies caused by | asbestosis
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| “Pleural Plaques” are seen on chest films | asbestosis
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| diagnosis is based largely on the history of exposure and latency period. 20-30 year exposure history | asbestosis
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| Allergic pulmonary condition caused by inhalation of organic materials | Hypersensitivity Pneumonitis
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| Known causative agents include bacteria, molds, human and animal proteins and resins | Hypersensitivity Pneumonitis
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| Abrupt onset of fever, cough & dyspnea within 4-8 hours of exposureInfiltrates in the mid-to-lower lung distributionResolution within 24 hours, after removal from exposureOften mistaken for community-acquired pneumonia, treated with antibiotics | Hypersensitivity Pneumonitis
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| Characterized as lung injury caused by the inhalation of nitrogen dioxide gas | Silo-Filler’s Disease
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| Approximately ___ of patients admitted to the burn unit have pulmonary injury due to smoke inhalation | 1/3
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| Carbon monoxide and cyanide poisoning impairs oxygenation causing tissue hypoxia | smoke inhalation
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| Ensuing airway edema and mucosal sloughing occurs | smoke inhalation
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| Routine use of corticosteroids and antibiotics has not been proven to be effective in treatment of | smoke inhalation
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| Topical administration of epinephrine may be used to reduce airway edema | smoke inhalation
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| The death rate among patients experiencing severe burn and inhalational injuries can be >__ | 50%
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| _____ cannot differentiate carboxyhemoglobin from oxyhemoglobin. | pulse oximetry
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| CO has a ____ higher affinity for hemoglobin than does oxygen | 250 X
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| ____ deposits in the alveoli and the interstitium results in irriversible fibrosis | Fibrin
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| Loss of functional alveolar-capillary units,Impaired gas exchange that leads to hypoxemia and hypercapnia, Impaired lung compliance (stiff lungs)Progresses into Restrictive Lung Disease: smaller lung volumes and capacities (TLC, Tidal Volumes) | interstitial lung disease
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| Patchy “Ground Glass” appearance, Reticular (network) pattern, Honeycombing (thick-walled cystic spaces) in the lung periphery | interstitial lung disease
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| A nodular inflammatory lesion that may contain epithelial cells, phagocytes or macrophages | granuloma
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| A form of coagulation necrosis | caseating
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| A systemic disease of unknown origin characterized by granulomatous inflammation of the lung | sarcoidosis
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| Systemic disorder involving multiple organ systems,Highest incidence in black women, Onset in the 3rd decade of life | sarcoidosis
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| Elevated ESR, Leukopenia, Elevated ACE levels (40-80% prevalence) | sarcoidosis
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| Requires tissue biopsy of a lymph node showing non-caseating granulomas | sarcoidosis
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| Long-term corticosteroid therapy, ACE levels will tend to drop | treatment for sarcoidosis
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| A condition characterized by the presence of vasculitis and granulomatous lesions affecting the respiratory tract and kidneys | Wegener’s Granulomatosis
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| Small vessel vasculitis, Granuloma formation inflammation, Necrosis | triad of symptoms for Wegener’s Granulomatosis
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| Nasal septum perforation, crusting and ulceration may present, Deep vein thrombosis and pulmonary emboli are common, “Saddle Nose” deformity is a late stage finding | Wegener’s Granulomatosis
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| Idiopathic condition involving alveolar (lung) hemorrhage and rapidly progressive glomerulonephritis | Goodpasture's syndrome
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| Most prevalent in men within the 3rd and 4th decade of life, Pathology is linked to glomerular antibodies | Goodpasture's syndrome
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| Immunosuppressive Therapy is treatment for | Goodpasture's syndrome
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