Vasculitis disorders
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Vasculitis | Inflammation and necrosis of blood vessels.
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Polyarteritis nodosa (PAN) | Acute necrotizing vasculitis of medium-sized muscular arteries. Men and whites. Thrombosis/ischemia. Fibrinoid necrosis. Hep B serospositivity 30%.
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Kawasaki Disease (mucocutaneous lymph node syndrome) | Acute necrotizing vasculitis. Infancy. Fever, rash, conjunctival lesions, oral lesions. Coronary aneurysms. Japan. Self-limiting.
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Giant cell arteritis (temporal cell arteritis) | Focal. Granulomatous. Temporal artery, aorta. Old age females. Most common vasculitis. Nodular thickening/reduced lumen. Fragmentation of internal elastic lamina. Vision impairment. Polymyalgia rheumatica.
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Hypersensitivity angiitis (microscopic polyangiitis, leukocytoclastic vasculitis) | Small vessels. Skin or systemic. Palpable purpura. Drugs, infections, tumors. Fibrinoid necrosis, extravasation of RBCs. p-ANCA. Glomerulonephritis/kidney failure.
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Churg-Strauss syndrome | P-ANCA. Granulomatous. Eosinophilia. Systemic. Young people with asthma/allergies.
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Takayasu arteritis. | Pulseless disease. Granulomatous thickening of aorta and large branches. Young Asian females. Panarteritis w/giant cells. Steroids/surgical reconstruction.
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Thromboangiitis obliterans (Buerger disease) | Occlusive. Medium/small arteries. Distal arms/legs. Smokers. Middle-age men. Gangrene. Amputations. Intermittent claudication.
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Wegener granulomatosis | Systemic necrotizing vasculitis. Granulomatous. Lungs, kidney, upper respiratory. Small vessels. Hematuria/proteinuria. Sinusitis/pneumonitis. C-ANCA. Cyclophosphamide.
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