Oncology
Quiz yourself by thinking what should be in
each of the black spaces below before clicking
on it to display the answer.
Help!
|
|
||||
|---|---|---|---|---|---|
| Typically induces cell transformation | Proto-oncoogene
🗑
|
||||
| The development of cancer cells.Cancer cells commonly inactivate inhibitor growth signals, evade apoptosis, have a limitless replicative potential, invade tissue, a sustained mutagenesis and undergo angiogenesis | Oncogenesis
🗑
|
||||
| Growth factors/receptors, Signal Transduction pathways, Transcription factors, Cell cyle control proteins, DNA repair enzymes, Apoptosis Proteins | Examples of oncogenes
🗑
|
||||
| Point mutation, Chromosomal translocation, Multiple copies of DNA, Frame shift mutation | Mechanisms in which proto-ocogenes become oncogenes
🗑
|
||||
| Regulates the G1 phase of the cell cycle | Cyclin D
🗑
|
||||
| Cyclin D binds to | CDK 4/6
🗑
|
||||
| Inhibitors of the cell cycle. Help to control the progession through the cell cycle | Cylin Dependent Inhibitors (CDI)
🗑
|
||||
| The formation of cyclin D/CDK 4/6 complex is inhibited by | p15, p16, p18, p19
🗑
|
||||
| Most cyclin/cdk complexes are inhibited by | p21
🗑
|
||||
| p21 is activated by | p53
🗑
|
||||
| This monitors DNA damage and activates p21 to inhibit cell division | p53
🗑
|
||||
| A monomeric G protein and a proto-oncogene | Ras
🗑
|
||||
| An example of a tumor suppressor | Retinoblastoma (Rb)
🗑
|
||||
| DNA repair is initiated by | p53
🗑
|
||||
| Tumor suppressor genes become oncogenic by | Deletions, Point mutations, DNA methylation
🗑
|
||||
| A loss-of-function mutation is an example of | tumor suppressors
🗑
|
||||
| A gain-of-function mutation is an example of | proto-oncogenes
🗑
|
||||
| Ras directly activates | Raf
🗑
|
||||
| MEK directly activates | MAPK
🗑
|
||||
| MAPK activates | Fos (a transcription factor)
🗑
|
||||
| Ras induces cell proliferation | True
🗑
|
||||
| Hedgehog is a proto-oncogene | True
🗑
|
||||
| The EGF receptor is an example of a proto-oncogene | True
🗑
|
||||
| The mitochondrial pathway and the membrane receptor pathway are two type of mechanisms that induce | Apoptosis
🗑
|
||||
| Activation of caspase-8 induces apoptosis | True
🗑
|
||||
| Activation of the ... receptor activate apoptosis through the activation of caspase-8 | Death
🗑
|
||||
| The activation of the ... pathway is elicited through the activation of Apaf-1, Cyt c, ATP, and pro-caspase-9 | Mitochondrial
🗑
|
||||
| Bcl-2 is an | Anti-apoptotic protein
🗑
|
||||
| Bax is a | Pro-apoptotic protein
🗑
|
||||
| The idea that more than one mutation is required for a normal cell to become a tumor | Multiple Hit Hypothesis
🗑
|
||||
| Benzopyrene (cigarettes), Aflatoxin B, Reactive oxygen species, DNA crosslinking agents, and Alkylating agents are chemicals that can cause | DNA damage
🗑
|
||||
| The inability to repair thymine dimers which are caused by UV irradiation | Xeroderma pigmentosum
🗑
|
||||
| Multiple TTAGGG repeats found at the ends of chromosomes | Telomeres
🗑
|
||||
| The enzyme responsible for creating telomeres and is often inactivated in adult cells but activated during oncogenesis | Telomerase
🗑
|
||||
| Defined as a limited capacity to divide before cells enter a non-proliferate state | Senescence
🗑
|
||||
| Caused by a translocation of the myc gene from chromosome 8 to 14 | Burkitt Lymphoma
🗑
|
||||
| Caused by a translocation between chromosomes 9 and 22 | Chronic Myelogenous Leukemia
🗑
|
Review the information in the table. When you are ready to quiz yourself you can hide individual columns or the entire table. Then you can click on the empty cells to reveal the answer. Try to recall what will be displayed before clicking the empty cell.
To hide a column, click on the column name.
To hide the entire table, click on the "Hide All" button.
You may also shuffle the rows of the table by clicking on the "Shuffle" button.
Or sort by any of the columns using the down arrow next to any column heading.
If you know all the data on any row, you can temporarily remove it by tapping the trash can to the right of the row.
To hide a column, click on the column name.
To hide the entire table, click on the "Hide All" button.
You may also shuffle the rows of the table by clicking on the "Shuffle" button.
Or sort by any of the columns using the down arrow next to any column heading.
If you know all the data on any row, you can temporarily remove it by tapping the trash can to the right of the row.
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.
Normal Size Small Size show me how
Normal Size Small Size show me how
Created by:
mhaynes
Popular Medical sets