Ch 24: ergot alkaloids, migraine medications, and serotonin receptor modulators
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| ergot alkaloids have what properties? | show 🗑
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| show | stimulation of 5HT1 (serotonin) receptors, or through blockade of 5HT2 (serotonin) receptors.
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| MOA of ergot alkaloids? | show 🗑
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| show | ergotamine and methysergide. they are "autocoids" meaning that they function as local hormones
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| show | ergotamine
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| show | 5HT2 serotonin antagonist, and by that means, is able to cause vasoconstriction. best used in prodromal phase
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| contraindications of ergotamine? | show 🗑
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| this is used in prevention of migraine, and is usually given during the prodorome. thus, it is only prophylactic, and is not intended for use during an active migraine attack. second lie drug. | show 🗑
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| tripatans have what ending? | show 🗑
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| show | sumatriptan
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| triptans are DOC for...? | show 🗑
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| all triptans should be avoided in patients with... | show 🗑
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| this is another migraine medicaiton, and is used occassionally in the prevention of migraine, although it is used more commonly for cluster headaches. triptans are considered superior to this medication for treatment of cluster headaches. | show 🗑
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| show | blocks the 5HT2 receptors.
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| these are two powerful anti emetics that affect serotonin receptors. they are 5HT3 antagonists receptors, activating CNS driven vomitting. thus, their blockade is very effective in preventing nausea and vomitting | show 🗑
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| show | metochlopramide
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| this is a 5HT1 antagonist. use is limited to anxiolysis | show 🗑
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