Ch 24: ergot alkaloids, migraine medications, and serotonin receptor modulators
Quiz yourself by thinking what should be in
each of the black spaces below before clicking
on it to display the answer.
Help!
|
|
||||
|---|---|---|---|---|---|
| ergot alkaloids have what properties? | vasoconstrictive properties
🗑
|
||||
| what are two major ways to induce vasoconstriction? | stimulation of 5HT1 (serotonin) receptors, or through blockade of 5HT2 (serotonin) receptors.
🗑
|
||||
| MOA of ergot alkaloids? | 5HT2 antagonists, and cuase vasoconstriction.
🗑
|
||||
| what are two ergots? | ergotamine and methysergide. they are "autocoids" meaning that they function as local hormones
🗑
|
||||
| one of several drugs of choice to treat moderate to severe migrains ("abortive therapy"), and can also be used to prevent migraine recurrence (prophylaxis). | ergotamine
🗑
|
||||
| MOA of ergotamine? | 5HT2 serotonin antagonist, and by that means, is able to cause vasoconstriction. best used in prodromal phase
🗑
|
||||
| contraindications of ergotamine? | pregnancy, peripheral vascular disease, andcoronary artery disease
🗑
|
||||
| this is used in prevention of migraine, and is usually given during the prodorome. thus, it is only prophylactic, and is not intended for use during an active migraine attack. second lie drug. | methysergide
🗑
|
||||
| tripatans have what ending? | tripatan
🗑
|
||||
| this is a 5HT1 antagonist and is generally a more powerful anti migraine medication than the ergot alkaloids. useful in both the prvention of migraine, and treatment of ongoing migraine | sumatriptan
🗑
|
||||
| triptans are DOC for...? | they are 5HT1 antagonists, and are the drug of choice for the abortive therapy of ongoing moderate to severe migraines.
🗑
|
||||
| all triptans should be avoided in patients with... | printzmetals angina, peripheral vascular disease, and uncontrolled hypertension. also, these should not be prescribed to patiens currently under therapy with SSRIs, SNRIs, or MAOIs
🗑
|
||||
| this is another migraine medicaiton, and is used occassionally in the prevention of migraine, although it is used more commonly for cluster headaches. triptans are considered superior to this medication for treatment of cluster headaches. | cyproheptadine
🗑
|
||||
| MOA of cyproheptadine? | blocks the 5HT2 receptors.
🗑
|
||||
| these are two powerful anti emetics that affect serotonin receptors. they are 5HT3 antagonists receptors, activating CNS driven vomitting. thus, their blockade is very effective in preventing nausea and vomitting | dolansetron and palonosetron.
🗑
|
||||
| 5HT4 antagonist and is also used as an anti-emetic. 5HT4 antagonism causes increased GI motility, thereby minimizing gastroparesis and vomitting | metochlopramide
🗑
|
||||
| this is a 5HT1 antagonist. use is limited to anxiolysis | buspirone
🗑
|
Review the information in the table. When you are ready to quiz yourself you can hide individual columns or the entire table. Then you can click on the empty cells to reveal the answer. Try to recall what will be displayed before clicking the empty cell.
To hide a column, click on the column name.
To hide the entire table, click on the "Hide All" button.
You may also shuffle the rows of the table by clicking on the "Shuffle" button.
Or sort by any of the columns using the down arrow next to any column heading.
If you know all the data on any row, you can temporarily remove it by tapping the trash can to the right of the row.
To hide a column, click on the column name.
To hide the entire table, click on the "Hide All" button.
You may also shuffle the rows of the table by clicking on the "Shuffle" button.
Or sort by any of the columns using the down arrow next to any column heading.
If you know all the data on any row, you can temporarily remove it by tapping the trash can to the right of the row.
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.
Normal Size Small Size show me how
Normal Size Small Size show me how
Created by:
aferdo01
Popular Medical sets