Ch 24: ergot alkaloids, migraine medications, and serotonin receptor modulators
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| ergot alkaloids have what properties? | show 🗑
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| show | stimulation of 5HT1 (serotonin) receptors, or through blockade of 5HT2 (serotonin) receptors.
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| show | 5HT2 antagonists, and cuase vasoconstriction.
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| what are two ergots? | show 🗑
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| one of several drugs of choice to treat moderate to severe migrains ("abortive therapy"), and can also be used to prevent migraine recurrence (prophylaxis). | show 🗑
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| show | 5HT2 serotonin antagonist, and by that means, is able to cause vasoconstriction. best used in prodromal phase
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| show | pregnancy, peripheral vascular disease, andcoronary artery disease
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| this is used in prevention of migraine, and is usually given during the prodorome. thus, it is only prophylactic, and is not intended for use during an active migraine attack. second lie drug. | show 🗑
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| show | tripatan
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| this is a 5HT1 antagonist and is generally a more powerful anti migraine medication than the ergot alkaloids. useful in both the prvention of migraine, and treatment of ongoing migraine | show 🗑
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| triptans are DOC for...? | show 🗑
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| all triptans should be avoided in patients with... | show 🗑
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| show | cyproheptadine
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| MOA of cyproheptadine? | show 🗑
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| these are two powerful anti emetics that affect serotonin receptors. they are 5HT3 antagonists receptors, activating CNS driven vomitting. thus, their blockade is very effective in preventing nausea and vomitting | show 🗑
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| show | metochlopramide
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| this is a 5HT1 antagonist. use is limited to anxiolysis | show 🗑
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