Ch 23: Anti-Angiotensins
Quiz yourself by thinking what should be in
each of the black spaces below before clicking
on it to display the answer.
Help!
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| anti angiotensins include what class of drugs? | ACE-I, ARBs, aldosterone antagonists
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| what diseases do anti angiotensins treat? | CHF, hypertension
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| MOA of ACE inhibitors? | prevent conversion of Angiotensin I to Angiotensin II
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| do ARBs cause cough? why or why not? | no, because it only blocks the receptor, so no increase in bradykinin, so no cough. blood pressure reduction tends to not be as significant.
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| this is an aldosterone antagonist, blocking the effects of aldosterone. accordingly, it prevents aldosterone mediated effects, preventing the aldosterone mediate uptake of sodium and water. | spironolactone
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| what type of diuretic is spironolactone? | potassium sparing diuretic. it blocks the aldosterone receptor
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| adverse effects of spironolactone? | hyperkalemia, metabolic acidosis, hormone related sid eeffects (menstrual irregularities and gynecomastia). the latter effect is because of structural similarity to sex hormones.
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