Stack #147907
Quiz yourself by thinking what should be in
each of the black spaces below before clicking
on it to display the answer.
Help!
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| Polypeptide GFs | inc cell size, increase mitosis (mitogens), increase survival, proto oncogenes--mutated genes cause CA)
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| GFs | locomotion, contractility, differentiation, angiogenesis
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| EGF | family proteins from platelets, macrophages, epithelial cells. Acts on keratinocytes to divide and acts on fibroblasts to produce granulation tissue. ERB-B2 (HER2/NEU) (receptor)
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| TGF-a | (transforming). made in macrophages, T cells, keratinocytes. Sim to EGF; also effect on hepatocytes
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| HGF | (Hepatocyte). made in mesenchymal cells; prolif of epithelium, endothelium, hepatocytes, effect on cell motility
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| VEGF | Vascular endothelial- made in mesenchymals cells, inc vascular permeability, mitogenic for endothelial cells, key substance in promotion granulation tissue
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| PDGF | platelet derived; made in platelets, but also many other cell types; chemotactic for many cells, mitogen for fibroblasts, induces repair, angiogenesis, another key player in granulation tissue
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| FGF | (fibroblast). made in many cells; chemotactic and mitogenic, for fibroblasts and keratinocytes (epithelial cells); angiogenesis, would contracture, and to make ECM stuff that fibroblasts make
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| TGF-B | (transforming). made in many cells, chemotactic for PMNs and many other types of cells.
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| KGF | (keratinocyte). made in fibroblasts; stims keratinocyte migration, proliferation, differentiation
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| IGF-1 | (Insulin-like). Made in macrophages, fibroblasts; stims sulfated proteoglycans, collagen, keratin migration, fibroblast proliferation-axn sim to GH
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| TNF | made in macrophages, mast cells, T cells; activates macrophages, key influence on other cytokines
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Created by:
sarah.edgar
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