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Advanced Patho EXAM 2

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Question
Answer
What is hypertension?   elevation of blood pressure  
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What BP readings determine HTN?   persistently above 140/90  
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List some risk factors of HTN.   age, race (african americans), obesity, nutrition and familial tendencies  
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What is the most common cause of coronary artery disease (CAD)?   atherosclerosis  
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What is CAD?   disorder of impaired coronary blood flow  
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List some risk factors for CAD.   F >55yrs; M >45yrs Family HX HTN, smoking, obesity,inactivity, poor diet, DM Lipids – total cholesterol >200 LDL >130, Trig >150 HDL<40  
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What is angina?   chest pain assoc w/ intermittent myocardial ischemia in insufficient time to result in cell death  
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In females, how can angina present?   as indigestion  
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What are the 3 types of angina?   stable, prinzmetal, and unstable  
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What is stable angina is relieved by?   rest and NTG (vasodilation and decreased workload)  
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Is prinzmetal angina predictable or unpredictable and why?   unpredictable; may be due to spasms  
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What is a myocardial infarction (MI)?   prolonged or total disruption of blood flow to myocardium causing irreversible cellular death  
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What is a transmural infarct?   involves entire ventricular wall thickness, common & severe, nearly all are in L ventricular wall  
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Describe subendocardial infarction.   less severe, most vulnerable to a reduction in blood flow, only portion of ventricular wall involved  
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True or false, the septum separates the heart into right and left sides.   True  
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List the 4 heart chambers.   Right atrium and ventricle; left atrium and ventricle  
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List the 2 valves on the right side of the heart.   Pulmonary and tricuspid  
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List the 2 valves on the left side of the heart.   Aortic and mitral (aka bicuspid)  
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Describe the circulatory pathway (how blood returns/leaves the heart)   Systemic circulation, vena cava, R atrium, tricuspid valve, R ventricle, Pulmonic valve, Pulmonic trunk/Pulmonary artery, lungs, pulmonary vein, L atrium, mitral valve, L ventricle, aortic valve, aorta, systemic circulation  
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The right side of the heart returns blood to the lungs via __________?   the pulmonary artery  
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The left side of the heart returns blood to the body via __________?   aorta  
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Narrowing or stricture of a blood vessel is known as?   stenosis  
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What is regurgitation?   blood flows backwards  
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True or false, murmurs may be present in both stenosis or regurgitation?   true  
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What is the most common septal defect?   Ventricular septal defect (VSD)  
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What is VSD?   an acyanotic (congestive) defect, opening b/t ventricles, produces increased workload for R side of heart  
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What kind of shunt/problems occur in VSD?   L-to-R shunt, w/ continued high pulm blood flow, pulm vascular obstructive disease develops; can eventually lead to shunt reversal and cyanotic sympotms  
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What is transposition of great arteries?   Aorta comes from R ventricle and pulmonary artery from L ventricle; resulting in 2 separate, non-communicating circulations =  
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What is the most common symptom in infant seen in transposition of great arteries?   cyanosis  
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What is dilated cardiomyopathy and what is the treatment?   dilation of all 4 heart chambers; heart transplant  
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Hypertrophic cardiomyopathy may cause what?   small SV, sudden death, DOE, angina  
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What may cause paroxysmal nocturnal dyspnea?   restrictive cardiomyopathy  
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What is RAA?   Renin-Angiotensin-Aldosterone System  
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What happens if the RAA system is activated?   If this system is activated, the following occurs: vasoconstriction increase BP hold on H2O & Na+  
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What are cardiac shunts?   they create an abnormal blood flow path  
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What occurs with a right to left shunt?   unoxygenated blood from the right side of heart enters the left and systemic circulation child may have cyanosis  
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What occurs with a left to right shunt?   oxygenated blood from left side of heart enters the right and is re-circulated through the lungs acyanotic defect right side has increased workload due to extra blood, over time right ventricular hypertrophy may occur  
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Describe Atrial Septal Defect (ASD)?   foramen ovale fails to close after birth acyanotic  
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If ASD is not correct, what may develop?   RVH  
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What are the 2 acyanotic congenital heart defects?   ASD and PDA  
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What is Patent Ductus Arteriosus (PDA)?   suppose to close at birth; if it doesn't harsh murmur is present  
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What is the most common cyanotic congenital heart defect?   Tetralogy of fallot  
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Cardiac muscle is called _________.   myocardium  
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What does Tetralogy of fallot consist of?   4 heart defects  
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True or false, medications are used to treat Tetralogy of Fallot.   False, total correction surgically is required.  
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What happens during the systole cardiac cycle?   ventricles are contracting  
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When the ventricles are relaxed and filling, this is known as ____________?   diastole portion of the cardiac cycle  
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