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Integumentary System

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Largest organ Accounts for 7% of body weight Varies in thickness from 1.5–4.4mm Divided into two distinct layers Epidermis Dermis   The Skin  
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lies deep to the dermis   Hypodermis  
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What are the functions of the Skin and Hypodermis?   Protection— from bumps, chemicals, water loss, UV radiation Regulation of body temperature Excretion— urea, salts, and water lost through sweat Production of vitamin D Sensory reception—keeps us aware of conditions at the body’s surface  
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4 main cell types of Epidermis   Keratinocytes -tratum spinosum; produce keratin a fibrous protein Melanocytes-basal layer; secrete pigment Tactile epithelial cells-basal layer; attached to sensory nerve endings Dendritic cells-stratum spinosum; part of immune system; macrophage-like  
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most abundant cell type in epidermis Arise from deepest layer of epidermis Produce keratin, a tough fibrous protein Produce antibodies and enzymes Dead at skin's surface   Keratinocytes  
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5 Layers of the Epidermis   A) Stratum basale (stratum geminativum) B) Stratum spinosum C) Stratum granulosum D) Stratum lucidum (only in thick skin) E) Stratum corneum  
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Deepest layer of epidermis Attached to underlying dermis Cells actively divide Stratum basale contains Merkel cells—associated with sensory nerve ending Melanocytes—secrete the pigment melanin   A) Stratum basale  
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“Spiny” appearance caused by artifacts of histological preparation Contains thick bundles of intermediate filaments (tonofilaments) Resist tension Contain protein prekeratin and star-shaped dendritic cells Function in immune system (as macrophages)   B) Stratum spinosum (spiny layer)  
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Consists of keratinocytes and tonofilaments Tonofilaments contain: Keratohyaline granules—help form keratin Lamellated granules—contain a waterproofing glycolipid   C) Stratum granulosum  
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Occurs only in thick skin Locations of thick skin—palms and soles Composed of a few rows of flat, dead keratinocytes   D) Stratum lucidum (clear layer)  
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Thick layer of dead keratinocytes and thickened plasma membranes Protects skin against abrasion and penetration   E) Stratum corneum (horny layer)  
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Second major layer of the skin Strong, flexible connective tissue Richly supplied with blood vessels and nerves   Dermis  
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2 layers of the dermis   Papillary layer—includes dermal papillae Reticular layer Deeper layer—80% of thickness of dermis  
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Creases on palms are called:   Flexure lines  
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Deep to the skin—also called superficial fascia Contains areolar and adipose CT Anchors skin to underlying structures Helps insulate the body   Hypodermis  
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3 pigments that contribute to skin color:   i) Melanin Most important pigment—made from tyrosine ii) Carotene Yellowish pigment from carrots and tomatoes iii) Hemoglobin Caucasian skin contains little melanin Allows crimson color of blood to show through  
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scalelike modification of epidermis Made of hard keratin   Nails  
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Parts of The Nail   Free edge Body Root Nail folds Eponychium—cuticle  
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Flexible strand of dead, keratinized cells Hard keratin—tough and durable   Hair  
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2 Parts of Hair   Root—imbedded in the skin Shaft—projects above skin's surface  
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3 layers of Hair   i) Medulla—central core ii) Cortex—surrounds medulla iii) Cuticle—outermost layer  
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Extend from epidermis into dermis   Hair follicles  
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Deep, expanded end of the hair follicle   Hair bulb  
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Knot of sensory nerves around hair bulb   Root plexus  
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Bundle of smooth muscle Hair stands erect when this contracts   Arrector pili muscle  
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Body hairs of women and children   Vellus hairs  
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Hair of scalp Axillary and pubic area (at puberty)   Terminal hairs  
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Occur over entire body Except palms and soles Secrete sebum—an oily substance   Sebaceous Glands  
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entire cell breaks up to form secretion Most are associated with a hair follicle   Holocrine secretion  
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Functions of sebum   Collects dirt; softens and lubricates hair and skin  
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glands (sudoriferous glands) widely distributed on body   Sweat glands  
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a blood filtrate 99% water with some salts Contains traces of metabolic wastes About 2% urea   Sweat  
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2 types of sweat glands   Eccrine gland (merocrine) Most numerous—produce true sweat Apocrine gland Confined to axillary, anal, and genital areas Musky odor-attracts mate Signal about immune system, MHC (Ceruminous glands and mammary glands are modified apocrine glands)  
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only upper epidermis is damaged from burns   First-degree burn  
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upper epidermis and upper part of dermis is also damaged from burns   Second-degree burn (Blisters appear Skin heals with little scarring)  
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Consumes thickness of skin Burned area appears white, red, or blackened   Third-degree burn  
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Least malignant and most common skin cancer   Basal cell carcinoma  
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Skin cancer that arises from keratinocytes of stratum spinosum   Squamous cell carcinoma  
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A cancer of melanocytes The most dangerous type of skin cancer   Melanoma  
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Develops from embryonic ectoderm   Epidermis  
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Develop from mesoderm   Dermis and hypodermis  
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Develop from neural crest cells   Melanocytes  
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vernix caseosa   produced by Fetal sebaceous glands  
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Fetal skin is well formed after the fourth month. At 5–6 months, the fetus is covered with lanugo (downy hairs)   Fetal skin is well formed after the fourth month. At 5–6 months, the fetus is covered with lanugo (downy hairs)  
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