Path
Quiz yourself by thinking what should be in
each of the black spaces below before clicking
on it to display the answer.
Help!
|
|
||||
|---|---|---|---|---|---|
| ab pain, ascites, hepatomegaly from obstruct of two or more major hepatic veins d/t thrombosis--> encephalopathy. Red-purple liver w tense capsule | Budd-Chiari
🗑
|
||||
| accumulate unconj bilirubin in brain->kernicterus | Erythroblastosis fetalis
🗑
|
||||
| Bridging fibrosis septa linking portal tracts, Parenchymal nodules of hepatocytes encircled by fibrosis, Disruption of entire liver architecture. Death of hepatocytes, deposit ECM, vasc reorganization | Cirrhosis
🗑
|
||||
| chronic CONJUGATED hyperbilirubinemia d/t defect in hepatocell excrete of bilirubin glucuronides across canalicular membrane by multidrug resistance prot 2. liver is Black | Dubin-Johnson synd
🗑
|
||||
| circular defective ssRNA Deltaviridae. Dependent on HBV. Only makes delta antigen (HDAg) | Hep D
🗑
|
||||
| extrahepat bile duct obstruct=biliary atresia, gallstones, stricture, panc CA. Pruritus, jaundice, dark urine, light stools, hepatosplenomegaly. Conjug hyperbilirubinemia, increase serum ALP, bile acids, cholest. Yellow-green liver, fibrous jigsaw septa | Secondary biliary cirrhosis
🗑
|
||||
| hepatocyte ballooning, lobular inflam, steatosis. Fat people. Elevated AST and ALT, AST/ALT ratio less than 1 (above 2 in alcoholic steatohep). | nonalcoholic steatohep (NASH)
🗑
|
||||
| Baby w prolonged conj hyperbilirubinemia. mostly caused by biliary atresia. jaundice, dark urine, light stools, hepatomega | Neonatal cholestasis
🗑
|
||||
| mutant ATP7Bimpaired copper excretion into bile and fail to incorporate Cu into ceruloplasmin. Cu build up in liver (chronic hep), brain (putamen atrophy), eye (Kayser-Fleischer rings). | Wilson disease
🗑
|
||||
| nothing to inhibit destructive proteasesemphysema and liver disease. PiS and PiZ (PiZZ is most common dysfnx). Round to oval cytoplasmic globular inclusions in hepatocytes | Alpha1-Antitrypsin def
🗑
|
||||
| partially dsDNA. Most recover from acute hep, some get fulminant hep, more get chronic hep (ground-glass hepatocytes), most are healthy carrier, some cirrhosis->hepatocell CA, less recover. Unprotect sex and IV drug use. Detect HBsAg or antibods to HBcAg | Hep B
🗑
|
||||
| ssRNA. Most common chronic blood infx/cause of liver disease. Most progress to chronic hep (20% cirrhose) (Fatty change of hepatocytes). Unprotect sex and IV drug. Lots of variability (quasispecies), no vaccine. Episodic elevate serum aminotransferases | Hep C
🗑
|
||||
| ssRNA Hepevirus. water-borne, zoonotic. High mortality when pregnant | Hep E
🗑
|
||||
| ssRNA Picornavirus, doesn’t cause chronic hep. IgM antibody then IgG antibody for years. | Hep A
🗑
|
||||
| UGT1A1 completely absent->very high unconj bilirubin->jaundice/icterus | Crigler-Najjar type 1
🗑
|
||||
| UGT1A1 greatly reduced->form monoglucuronidated bilirubin->extraordiarily yellow skin | Crigler-Najar type 2
🗑
|
||||
| UGT1A1 reduced a little, no big deal | Gilbert Syndrome
🗑
|
||||
| viable hepatocytes unable to function properly (tetracycline tox and acute fatty liver of pregnancy (AFLP)) | Hep dysfnx
o Jaundice, hypoalbuminemia->periph edema, hyperammonemia->hepat encephalopathy, fetor hepaticus = “musty” or “sweet and sour” body odor from mercaptans, hyperestrogenemia->palmar erythema and spider angiomas and hypogonadism and gynecomast
🗑
|
||||
| young women on birth control. Benign. HNF1alpha and Beta-catenin. Pale biley | Hepatic Adenoma
🗑
|
||||
| most common liver tumor of kids. Activates WNT/beta-catenin. Beckwith-Weidmann | Hepatoblastoma
🗑
|
||||
| most common cause of hepat fail, cirrhosis | Chronic Hep fail
🗑
|
||||
| most common cause of chronic liver disease in US. | Nonalcoholic Fatty Liver (NAFLD)
🗑
|
||||
| most common benign liver tumors. Red-blue soft nodules | Cavernous hemangiomas
🗑
|
||||
| maternal HTN, proteinuria, peripheral edema, coag abnorm, DIC. Plus hyper-reflex and convulsions = eclampsia. o HELLP synd = Hemolysis, Elevated Liver enzymes, Low Platelets. | Preeclampsia
🗑
|
||||
| massive hepatic necrosis w encephalopathy caused most often by drugs (acetomenophin), also Hep A and B | Acute Hep failure
🗑
|
||||
| malignancy of biliary tree. Most are extrahepatic (perihilar Klatskin tumors). Firm gray w/in bile duct walls. Malignant adenocarcinoma. IL6 overexpress->AKT and anti-apoptotic prot MCL1 active. | Cholangiocarcionoma
🗑
|
||||
| inflamm and obliterative fibrosis of intrahepat and extrahepat bile ducts. Associated w IBD. Atypical p-ANCAs, hypergammaglobulinemia. Men. Onion-skin fibrosis And another thing: - Nutmeg liver w left sided heart fail or shock | Primary Sclerosing Cholangitis (PSC)
🗑
|
||||
| most common primary liver cancer. Lots of things lead to it (hepatitis, cirrhosis). Malignant | Hepatocell Carcinoma (HCC)
🗑
|
||||
| most common biliary tract anomaly creates Phrygian cap | Folded Fundus
🗑
|
Review the information in the table. When you are ready to quiz yourself you can hide individual columns or the entire table. Then you can click on the empty cells to reveal the answer. Try to recall what will be displayed before clicking the empty cell.
To hide a column, click on the column name.
To hide the entire table, click on the "Hide All" button.
You may also shuffle the rows of the table by clicking on the "Shuffle" button.
Or sort by any of the columns using the down arrow next to any column heading.
If you know all the data on any row, you can temporarily remove it by tapping the trash can to the right of the row.
To hide a column, click on the column name.
To hide the entire table, click on the "Hide All" button.
You may also shuffle the rows of the table by clicking on the "Shuffle" button.
Or sort by any of the columns using the down arrow next to any column heading.
If you know all the data on any row, you can temporarily remove it by tapping the trash can to the right of the row.
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.
Normal Size Small Size show me how
Normal Size Small Size show me how
Created by:
Jakphooey
Popular Medical sets