Malignant Lymphoma: Hodgkin Lymphoma
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| What is the main difference between the cellularity of the tumor mass in Hogdkin Lymphoma (HL) and non-Hodgkin Lymphoma (NHL)? | Neoplastic cells accounts for only a minority of the tumor mass, most of which is reactive inflammatory cells in HL
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| What population is typically diagnosed with Hodgkin Lymphoma? | Young adults (15-35yrs), but also occur in older adults (>50yrs).
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| Describe the pattern of spread of Hogdkin Lymphoma | The spread of HL is nonrandom, with dissematination via lymphatics to contiguous lymph node groups including the spleen.
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| What are B symptoms? | Fever, night sweats, or weight loss >10% of body weight
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| What is the immunophenotypic profile of Reed-Sternberg Cells? | LeuM1 (CD15)+, Ki-1 (CD30)+, and LCA (CD45)+
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| What are the morphologic features of Reed-Sternberg cells? | RS cells are large binucleate cells with dispersed chromatin, inclusion-like macronucleoli, and abundant eosinophilic cytoplasm.
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| What are the diagnostic features on histological examination of nodal tissue for Hodgkin Lymphoma? | HL typically effaces nodal architecture, forming a mass of characteristic reactive inflammatory cells with an admixed smaller population of large dysplatic Reed-Sternberg Cells.
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| What is the most common type of Hodgkin Lymphoma? | Nodular Sclerosis Hodgkin Lymphoma
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| What is the only type of Hogdkin Lymphoma that affects females more than males? | Nodular Sclerosis Hodgkin Lymphoma
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| What are the physical findings of Nodular Sclerosis Hodgkin Lymphoma? | (1) Cervical adenopathy and/or (2) Mediastinal mass
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| What are the histologic features of Nodular Sclerosis Hodgkin Lymphoma? | (1) Capsular fibrosis and (2) Dense bands of connective tissue that efface nodal archiecture and give a nodular appearnce. The nodules contain numerous inflammatory cells and scattered Reed-Sternberg Cells. The RS cells have a lacunar appearnce.
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| Type of Hogkin Lymphoma that typically affects middle-aged to elderly males. The Reed-Sternberg cells typically have a binucleate form. | Mixed Cellularity Hogdkin Lymphoma
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| Variant of Hodgkin Lymphoma that presents with fever, peripheral blood cytopenias, and adenopathy(more abdominal adenopathy). Lymphocytes are fewer in number and RS cells predominate over the reactive components. | Lymphocyte Depletion Hodgkin Lymphoma
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| A variant of Hodgkin Lymphoma that mimics Lymphocyte Predominant Hodgkin Lymphoma but has an immunophenotype of CD45-, CD15+, and CD30+. | Lymphocyte-rich Hodgkin Lymphoma
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| What is the immunophenotypic profile of Lymphocyte Predominance Hodgkin Lymphoma? | CD45+, CD15-, CD30-, CD20+
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| A variant of Hodgkin Lymphoma typically found in asymptomatic young males with cervical or axillary adenopathy. Histologically, the predominant cell is a small lymphocyte and RS cells are few in number with a popcorn appearance. | Lymphocyte Predominance Hodgkin Lymphoma
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