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Lecture 23

Malignant Lymphoma: Hodgkin Lymphoma

What is the main difference between the cellularity of the tumor mass in Hogdkin Lymphoma (HL) and non-Hodgkin Lymphoma (NHL)? Neoplastic cells accounts for only a minority of the tumor mass, most of which is reactive inflammatory cells in HL
What population is typically diagnosed with Hodgkin Lymphoma? Young adults (15-35yrs), but also occur in older adults (>50yrs).
Describe the pattern of spread of Hogdkin Lymphoma The spread of HL is nonrandom, with dissematination via lymphatics to contiguous lymph node groups including the spleen.
What are B symptoms? Fever, night sweats, or weight loss >10% of body weight
What is the immunophenotypic profile of Reed-Sternberg Cells? LeuM1 (CD15)+, Ki-1 (CD30)+, and LCA (CD45)+
What are the morphologic features of Reed-Sternberg cells? RS cells are large binucleate cells with dispersed chromatin, inclusion-like macronucleoli, and abundant eosinophilic cytoplasm.
What are the diagnostic features on histological examination of nodal tissue for Hodgkin Lymphoma? HL typically effaces nodal architecture, forming a mass of characteristic reactive inflammatory cells with an admixed smaller population of large dysplatic Reed-Sternberg Cells.
What is the most common type of Hodgkin Lymphoma? Nodular Sclerosis Hodgkin Lymphoma
What is the only type of Hogdkin Lymphoma that affects females more than males? Nodular Sclerosis Hodgkin Lymphoma
What are the physical findings of Nodular Sclerosis Hodgkin Lymphoma? (1) Cervical adenopathy and/or (2) Mediastinal mass
What are the histologic features of Nodular Sclerosis Hodgkin Lymphoma? (1) Capsular fibrosis and (2) Dense bands of connective tissue that efface nodal archiecture and give a nodular appearnce. The nodules contain numerous inflammatory cells and scattered Reed-Sternberg Cells. The RS cells have a lacunar appearnce.
Type of Hogkin Lymphoma that typically affects middle-aged to elderly males. The Reed-Sternberg cells typically have a binucleate form. Mixed Cellularity Hogdkin Lymphoma
Variant of Hodgkin Lymphoma that presents with fever, peripheral blood cytopenias, and adenopathy(more abdominal adenopathy). Lymphocytes are fewer in number and RS cells predominate over the reactive components. Lymphocyte Depletion Hodgkin Lymphoma
A variant of Hodgkin Lymphoma that mimics Lymphocyte Predominant Hodgkin Lymphoma but has an immunophenotype of CD45-, CD15+, and CD30+. Lymphocyte-rich Hodgkin Lymphoma
What is the immunophenotypic profile of Lymphocyte Predominance Hodgkin Lymphoma? CD45+, CD15-, CD30-, CD20+
A variant of Hodgkin Lymphoma typically found in asymptomatic young males with cervical or axillary adenopathy. Histologically, the predominant cell is a small lymphocyte and RS cells are few in number with a popcorn appearance. Lymphocyte Predominance Hodgkin Lymphoma
Created by: UVAPATH4