Cytolpathology Tutorial
Quiz yourself by thinking what should be in
each of the black spaces below before clicking
on it to display the answer.
Help!
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| What is carincoma in situ | when the epithelium is completely replaced by cells having the characteristics of "cancer" cells
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| What is dysplasia | epithelial changes "less than" carcinoma in situ, usually graded as mild, moderate or severe
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| What is the CIN for severe dysplasia | CIN III
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| What is the CIN for carcinoma in situ | CIN III
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| What are some limitations of cytopathology | Hard to classify tumor type, specimen is lmitied to the surface of the lesion, extent and depth of invasion cannot be determined, exact location may not be pinpointed
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| The accuracy of cytodiagnosis is dependent on ??? factors | Experience of the collector and examiner, sampling method used, and target organ to be sampled
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| Is cytologic testing more sensitive or specific | Speceificity is higher (can rule in (spIN) not rule out snOUT)
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| What are some causes of error in cytodiagnosis | Inadequate sampling, Poor fixation or inadequate cell preservation, suboptimal laboratory techniques and staining
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| What is the best indicator of the biological potential of the cell | the cell nucleus
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| What do the nuclei of malignant cells look like | enlarged hyperchromatic nuclei leading to an increased nuclear;cytoplasmic ratio
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| What does it mean when a nucleus is enlarged | there is DNA synthesis
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| What does hyperchromasia indicate | More DNA/chromatin per unit area, DNA/RNA synthesis
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| What does it mean when there is a high N:C ratio | cell is differentiated more likely proliferating
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| what does it indicate when the chromatin are irregular | more nuclear activity in more areas of the nucleus, active transcription in areas of euchromatin
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Created by:
UVAPATH1
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